Elagolix, sold under the brand name Orilissa, is a gonadotropin-releasing hormone antagonist (GnRH antagonist) medication which is used in the treatment of pain associated with endometriosis in women. [1][2][3][7][6][4][8][9] It is also under development for the treatment of uterine fibroids and heavy menstrual bleeding in women. [9] .

2023年4月4日 · Elagolix is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if elagolix is safe and effective in children. Elagolix may cause serious side effects, including: bone loss (decreased bone mineral density). While you are taking elagolix, your estrogen levels will be low.

Orilissa是一种口服促性腺激素释放激素（GnRH）拮抗剂，由艾伯维（AbbVie）与合作伙伴Neurocrine Biosciences开发，于2018年7月获得美国FDA批准，用于治疗与子宫内膜异位症（EMs）相关的中度至重度疼痛。 目前，Orilissa用于子宫肌瘤女性患者治疗月经过多（HMB）的新药申请正在接受 FDA 的审查。 如果获得批准，Orilissa将为治疗子宫肌瘤相关月经过多（HMB）提供一种额外的口服药物治疗方案。

Background Elagolix is an oral small molecule second-generation nonpeptide gonadotropin-releasing hormone (GnRH) antagonist drug that can quickly and reversibly inhibit female gonadotropins and ovarian sex hormones. Previous randomized controlled trials (RCTs) have evaluated the efficacy and safety of elagolix alone or in combination with add ...

ORILISSA ® (elagolix) is a prescription medicine used to treat moderate to severe pain associated with endometriosis. It is not known if ORILISSA is safe and effective in children.

ORILISSA is a gonadotropin-releasing hormone (GnRH) receptor antagonist indicated for the management of moderate to severe pain associated with endometriosis. (1) Moderate hepatic …

2018年8月27日 · Elagolix（艾拉戈利）是一种短效促性腺激素释放激素（GnRH）拮抗剂，Elagolix针对下丘脑GnRH的生物学靶点，通过阻断GnRH，可以快速可逆、剂量依赖性地抑制性腺的分泌，从而抑制性激素，如雌二醇，黄体酮和睾酮的循环水平。

Elagolix is a medication that treats endometriosis. This condition causes painful and heavy periods, as well as fertility issues. It occurs when endometrial-like tissue grows outside your uterus. You can take this tablet by mouth with a glass of water as directed.

Elagolix is used to manage pain due to endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes infertility, pain before and during menstrual periods, pain during and after sexual activity, and heavy or irregular bleeding).

ORILISSA® (elagolix) is an oral pill taken daily to treat 3 common endometriosis pain symptoms: painful periods, pelvic pain between periods, and pain with sex. Learn about Risks and Benefits.