2025年3月28日 · EIF4A1 (Eukaryotic Translation Initiation Factor 4A1) is a Protein Coding gene. Diseases associated with EIF4A1 include Leukemia, Acute Myeloid and Hematologic Cancer. Among its related pathways are Peptide chain elongation and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.

Eukaryotic initiation factor 4A-I (also known as eIF4A1 or DDX2A) is a 46 kDa cytosolic protein that, in humans, is encoded by the EIF4A1 gene, which is located on chromosome 17.

真核起始因子 4A （英語： eukaryotic translation Initiation Factor 4A，简称为 eIF4A）是一种 ATP 依赖性 RNA 结合蛋白，一种RNA依赖性 ATP酶，和一种RNA 解旋酶，它在 真核翻译 起始进程中发挥重要作用。 它被认为可以解开 mRNA 的 5'端 非翻译区的二级和三级结构，以使 核糖体 的附着更容易，同时允许核糖体进行 起始密码子 扫描。 [1] eIF4A在人体中有三个亚型：eIF4A-1、eIF4A-2和eIF4A-3。 eIF4A是 DEAD盒 RNA解旋酶超家族成员，其 氨基酸 序列中具有8个保守 …

2024年11月8日 · Eukaryotic initiation factor 4 A (eIF4A) plays critical roles during translation initiation of cellular mRNAs by forming the cap-binding eIF4F complex, recruiting the 40S small ribosome...

2025年1月8日 · eIF4A 是一种 ATP 依赖的 RNA 解旋酶，能够解开 mRNA 5’ 非翻译区（5’ untranslated region, 5’ UTR）的二级结构，帮助 43S 前起始复合物（preinitiation complex, PIC）扫描 5’ UTR 以找到起始密码子。 eIF4A 有两个高度同源的亚型：eIF4A1 和 eIF4A2。 尽管它们在体外可以自由交换并参与 eIF4F 复合物的形成，但它们在体内的生物学功能和分子机制尚未完全阐明。 B 细胞是免疫系统中的重要组成部分，负责产生抗体以应对感染和疾病。

eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma. eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model. Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.

2024年5月21日 · Here we show that eIF4A1 enhances translational repression during the inhibition of mechanistic target of rapamycin complex 1 (mTORC1), an essential kinase complex controlling cell proliferation.

2025年3月25日 · All mRNAs require eukaryotic translation initiation factor (eIF) 4A1 for translation through its different functions: loading of the pre-initiation complex onto mRNAs and unwinding of RNA structure. eIF4A1 is the catalytic subunit of the cap- binding eIF4F complex and presumed to select the mRNAs for translation through these activities, instruc...

Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022] 生物活性分子 (9)

In this review, we explored the predicted structures of the three eIF4A isoforms (eIF4A1, eIF4A2, and eIF4A3), and discussed possible explanations for which function during different translation stages (initiation, mRNA localization, export, and mRNA splicing).