自身免疫性脑脊髓炎（EAE）动物模型的建立 - 知乎
实验性自身免疫性脑脊髓炎（experimental autoimmune encephalomyelitis，EAE）是一种以特异性致敏的CD4+T细胞介导为主的，以中枢神经系统内小血管周围出现单个核细胞浸润及髓鞘脱 …
Opposing T cell responses in experimental autoimmune ... - Nature
2019年8月7日 · Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4 +, CD8 + …
Pathogenic function of bystander-activated memory-like CD4
2019年2月12日 · From our study, we demonstrate an important role for antigen non-related bystander CD4 + T cells in EAE pathogenesis, which are activated by IL-1β together with IL …
Induction of passive EAE using myelin-reactive CD4+ T cells
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease of the central nervous system (CNS) often used as a model for the early inflammatory stages of multiple …
NAD+ protects against EAE by regulating CD4+ T-cell ... - Nature
2014年10月7日 · Here we show that nicotinamide adenine dinucleotide (NAD +) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing …
EAE Induction by Passive Transfer of MOG-specific CD4 - PubMed
2017年7月5日 · Here we describe protocols for passive transfer model of EAE using freshly isolated (MOG)-specific CD4 + T cells or periodically restimulated MOG-specific CD4 + T cell …
Direct modulation of myelin-autoreactive CD4+ and CD8+ T cells in EAE …
2018年6月27日 · Results: Four infusions of the tNPs durably ameliorated EAE with a marked reduction of clinical score, neuroinflammation and demyelination. They were distributed in …
自身免疫性脑脊髓炎的发病机理 - 科学网
2019年8月22日 · 美国斯坦福大学医学院Mark M. Davis课题组发现了实验性自身免疫性脑脊髓炎（EAE）中T细胞反应的对抗机制，相关论文发表在2019年8月22日出版的《自然 ...
通过MOG特异性CD4+ T细胞的被动转移诱导EAE - Bio-protocol
在这里，我们描述了使用MOG特异性CD4 + T细胞的被动转移EAE模型的详细方案，其适合于在体内跟踪自体CD4 + sup + T细胞。虽然已经报告了EAE协议（Racke，2001），但我们特别关 …
Direct modulation of myelin-autoreactive CD4+ and CD8+ T cells in EAE …
In multiple sclerosis (MS), myelin antigen-autoreactive CD4 + T cells and CD8 + T cells target and destroy myelin sheath on the nerve cells, thereby leading to substantial neuroinflammation, …