Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that in humans is encoded by the ERAP1 gene. This M1 zinc aminopeptidase is involved in the antigen processing and presentation pathway. ERAP1 is mainly located in the endoplasmic reticulum (ER), where it trims peptides at their N-terminus, adapting them for presentation by MHC class I ...

内质网氨肽酶 1： 该基因编码的蛋白质是一种氨肽酶，参与修剪 HLA I 类结合前体，以便它们可以呈现在 MHC I 类分子上。编码的蛋白质作为单体或与 ERAP2 形成异二聚体。这种蛋白质还可能通过使血管紧张素 II 失活而参与血压调节。已为该基因发现编码两种不同亚型的三种转录变体。[RefSeq 提供，2010 ...

2025年3月30日 · ERAP1 (Endoplasmic Reticulum Aminopeptidase 1) is a Protein Coding gene. Diseases associated with ERAP1 include Peeling Skin-Leukonuchia-Acral Punctate Keratoses-Cheilitis-Knuckle Pads Syndrome and Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads.

2023年3月30日 · erap1在抗原加工和修饰n端延伸肽到mhci类分子表达的最佳大小中起主要作用。 研究证明ERAP1可以形成二聚体复合物，更有效地切割残基。 除了ERAP1的主要酶促功能及其对MHC I类介导的抗原处理途径的贡献外，它在免疫系统和体内止血中也有几个关键功能。

Introduction: Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) is a key regulator of the peptide repertoire displayed by Major Histocompatibility Complex I (MHC I) to circulating CD8 + T cells and NK cells. Studies have highlighted the essential requirement for the generation of stable peptide MHC I in regulating both innate and adaptive immune ...

2025年2月8日 · ERAP1 as an emerging therapeutic target for medulloblastoma. A proposed HLA-B*27 screening method for ankylosing spondylitis detection based on tag-single nucleotide polymorphisms: a preliminary study. ERAP1 Controls the Interaction of the Inhibitory Receptor KIR3DL1 With HLA-B51:01 by Affecting Natural Killer Cell Function.

2022年3月4日 · Here, we investigated the role of ERAP1 in suppressing inflammasome pathways and their dependence on ER stress responses. Using bone marrow-derived macrophages (BMDMs), we found that loss of ERAP1 in macrophages resulted in exaggerated production of IL-1β and IL-18 and augmented caspase-1 activity, relative to wild type macrophages.

Aminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for ...

2011年4月10日 · ERAP1 trims antigen precursors to fit into MHC class I proteins. To fulfill this function, ERAP1 has unique substrate preferences, trimming long peptides but sparing shorter ones.

The ERAP1 gene provides instructions for making a protein called endoplasmic reticulum aminopeptidase 1. As its name suggests, this protein is active in a cellular structure called the endoplasmic reticulum, which is involved in protein processing and transport.