2025年3月30日 · DSC1 (Desmocollin 1) is a Protein Coding gene. Diseases associated with DSC1 include Subcorneal Pustular Dermatosis and Iga Pemphigus . Among its related pathways are Innate Immune System and Keratinization .

IgA 天疱疮的一种亚型是一种危及生命的自身免疫性疾病，其特征是存在靶向编码蛋白的自身抗体。 桥粒家族成员排列在 18 号染色体上的两个簇中。 该基因的可变剪接导致多个转录变体。 这些变体中至少有一个编码前原蛋白，该前原蛋白经过蛋白水解处理以生成成熟蛋白。 [RefSeq 提供，2015 年 11 月] The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily.

Desmocollin-1 is a protein that in humans is encoded by the DSC1 gene. [5] [6] The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily.

Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC.

DSC1 expression is significantly downregulated in human masticatory mucosa during wound healing; Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC.

DSC1是位于18号染色体的 基因。 该基因编码的蛋白质是钙依赖性糖蛋白，是钙黏着蛋白超家族的桥粒胶体亚家族的成员。 这些桥粒家族成员与桥粒芯蛋白一起主要在上皮细胞中发现，在那里它们构成桥粒体细胞-细胞连接的粘附蛋白，是细胞粘附和桥粒形成的必需物质。 IgA天疱疮的一种亚型，一种危及生命的自身免疫性疾病，其特征是存在靶向编码蛋白的自身抗体。 桥粒家族成员排列在18号染色体上的两个簇中。 该基因的可变剪接导致多个转录物变体。 这些变体中的至少一个 …

2023年8月24日 · Desmocollin-1 (DSC1) is a desmosomal transmembrane glycoprotein that maintains cell-to-cell adhesion. DSC1 was previously associated with lymph node metastasis of luminal A breast tumors and was found to increase migration and invasion of MCF7 cells in vitro.

2009年2月10日 · Gene Ontology (GO) annotations organized by slimming set. Showing features for topological domain, transmembrane. Showing features for natural variant. We now provide the "Disease & Variants" viewer in its own tab. The viewer provides 1,141 variants from UniProt as well as other sources including ClinVar and dbSNP. Go to variant viewer.

2024年3月7日 · DSC1蛋白（Desmocollin 1）是一种重要的细胞附着蛋白，属于角蛋白家族的一员。 它主要存在于表皮和心肌等组织中，在细胞间连接的形成和细胞的稳定性方面发挥着重要作用。

2011年7月1日 · Drosophila Sodium Channel 1 (DSC1) was predicted to encode a sodium channel based on a high sequence similarity with vertebrate and invertebrate sodium channel genes. However, BSC1, a DSC1 ortholog in Blattella germanica, was recently shown to encode a cation channel with ion selectivity toward Ca 2+.