2015年7月16日 · Overview of Medetomidine (Domitor®) for Cats and Dogs. Medetomidine, commonly known by the brand name Dormitor, is an injectable drug used for sedation in dogs and cats. Medetomidine belongs to a class of drugs known as alpha 2 adrenergic agonists and is similar to clonidine and xylazine.

It is approved for dogs in the United States, and distributed in the United States by Pfizer Animal Health and by Novartis Animal Health in Canada under the product name Domitor. Starting in 2022 Medetomidine has been detected in the US in …

Domitor (medetomidine hydrochloride) is a synthetic α2-adrenoreceptor agonist with sedative and analgesic properties. The chemical name is (±)-4-[1-(2,3-dimethylphenyl) ethyl]-1H-imidazole monohydrochloride.

Zoetis offers Dexdomitor, a sedative and analgesic for dogs and cats to facilitate clinical procedures.

2023年10月30日 · Anesthesia: Domitor is suitable for use as an anesthetic premedication prior to general anesthesia. Premedication dosing guide: Medetomidine has marked anaesthetic-sparing effects. It is essential to reduce appropriately the dose of anaesthetic induction and maintenance agents in animals that have been given the product.

在介导本品的主要药理和治疗效应中，α2a 受体亚型 起着重要作用，α2a受体存在于 突触 前和突触后，主要涉及抑制 去甲肾上腺素 的释放和 神经元 的兴奋。 本品通过激动 突触前膜 α2受体，抑制了去甲肾上腺素的释放，并终止了疼痛信号的传导；通过激动 突触后膜 受体，右美托咪定抑制 …

Les effets du Domitor peuvent être éliminés par l’administration d’un alpha-2 antagoniste, comme l'atipamézole, à condition que l'arrêt de la sédation ne soit pas dangereuse pour l’animal (l'atipamézole ne stoppe pas les effets de la kétamine qui, utilisée seule, peut causer des crises convulsives chez les chiens et des crampes ...

Domitor is suitable for use as an anaesthetic premedication prior to general anaesthesia. Premedication dosing guide: Medetomidine has marked anaesthetic-sparing effects.

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2023年10月30日 · When Domitor is administered, the animal should be allowed to rest in a maximally quiet place. Before any procedure is started or other drugs are administered, sedation should be allowed to reach its peak effect, which occurs at about 10 to 30 min, depending on route of administration.