Detomidine is an imidazole derivative and α 2-adrenergic receptor agonist, [1] used as a large animal sedative, primarily used in horses. It is usually available as the salt detomidine hydrochloride. It is a prescription medication available to …

Detomidine is used primarily as a sedative, anesthetic adjunct, and analgesia. It is used in horses more often than in other species. When used to treat pain from colic in horses, the duration of effect is approximately 3 hours (20 or 40 mcg/kg). Detomidine also has been administered for epidural analgesia.

With 30 years of use, Dormosedan® Sterile Solution (detomidine hydrochloride) provides veterinarians with safe and reliable sedation and analgesia that was rated in 2023 as the highest of all equine sedatives for efficacy, safety and reliability. 1,2

2016年2月26日 · Detomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. This drug is prescribed by veterinarians and is marketed as Dormosedan. Currently, it is only approved by the FDA for use in horses but has been studied for use in other large animals. Type Small ...

Dormosedan®, a non-narcotic sedative and analgesic, is a potent α 2 -adrenoreceptor agonist which produces sedation and superficial and visceral analgesia which is dose dependent in its depth and duration.

2014年6月17日 · Detomidine hydrochloride is used to calm excitable horses and to provide relief from abdominal pain, facilitating procedures such as bronchoscopy, bronchoalveolar lavage, nasogastric intubation, nonreproductive rectal palpations, and suturing skin lacerations.

2025年3月2日 · Dormosedan ®, a non-narcotic sedative and analgesic, is a potent α 2 -adrenoreceptor agonist which produces sedation and superficial and visceral analgesia which is dose dependent in its depth and duration.

2022年5月16日 · Detomidine causes depression of gastrointestinal motility due to decrease in smooth muscle activity, increases blood glucose levels due to inhibition of insulin release, and increases production of urine 2 to 4 hours after treatment.

Dexmedetomidine is an α 2 -adrenoceptor agonist with sedative, anxiolytic, sympatholytic, and analgesic-sparing effects, and minimal depression of respiratory function. It is potent and highly selective for α 2 -receptors with an α 2:α 1 ratio of 1620:1.

2020年11月1日 · In the pilot study, the sedative effects of incremental doses of 40–200 μg kg−1 detomidine gel (Dormosedan Gel; Zoetis Inc.) and 20–70 μg kg−1 parenteral detomidine hydrochloride (Dormosedan; Zoetis Inc.) were evaluated in two alpacas after intravaginal and IV administration, respectively.