Denosumab, sold under the brand name Prolia among others, is a human monoclonal antibody used for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone.

2025年3月10日 · Prolia (denosumab) is an injection that is administered subcutaneously (under the skin) once every 6 months by a healthcare provider to treat osteoporosis in postmenopausal women at high risk for fracture, to treat glucocorticoid-induced osteoporosis, and to increase bone mass in men and women receiving certain treatments.

2025年3月1日 · It is used to prevent bone problems in patients with multiple myeloma and bone metastases (cancer that has spread) from tumors. Denosumab is also used to treat giant cell tumor of the bone that cannot be removed by surgery.

3 天之前 · Denosumab is a human monoclonal antibody that works by inhibiting RANKL (receptor activator of nuclear factor kappa-B ligand), a protein essential for osteoclasts' formation, function, and survival. By inhibiting RANKL, denosumab decreases bone resorption and increases bone mass and strength.

DENOSUMAB (den oh sue mab) slows bone breakdown. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more.

2024年2月28日 · Denosumab is a bone anti-resorptive drug used for the treatment of the following: FDA-Approved Indications. Prevention of skeletal-related events: Denosumab is indicated for bone pain and fractures secondary to multiple myeloma or bone metastases from solid tumors. Used in conjunction with treatments for primary malignancy. [1] .

2024年7月3日 · What is Prolia used for? Prolia (denosumab) is commonly used to treat osteoporosis, a condition in which the bones are thinner, weaker, and more prone to breakage. Prolia may be prescribed for...

Denosumab is recommended for men and postmenopausal women with osteoporosis who are at high risk of fractures [15, 16].It is also a treatment option for glucocorticoid-induced osteoporosis [], and for patients undergoing hormone-ablative therapies, such as those with early breast cancer receiving aromatase inhibitors or non-metastatic prostate cancer undergoing androgen …

Denosumab injection products come as a solution (liquid) to be injected subcutaneously (under the skin) in your upper arm, upper thigh, or stomach area. It is usually injected by a doctor or nurse in a medical office or clinic.

Prolia ® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Read More. This site is for U.S. residents only. Is Prolia® Right for Me? Is Prolia right for me?