Primary Structure and Phosphorylation of Dentin Matrix Protein 1 (DMP1 …
To assess whether different SIBLINGs regulate biomineralization in a similar manner and how phosphorylation impacts their activity, we studied the effects of two SIBLINGs, dentin matrix protein 1 (DMP1) and dentin phosphophoryn (DPP), …
Glycosylation of Dentin Matrix Protein 1 is critical for ... - Nature
2015年12月4日 · Dentin matrix protein 1 (DMP1) is a highly expressed bone extracellular matrix protein that regulates both bone development and phosphate metabolism. After...
牙本质基质蛋白-1的研究进展 - 牙本质基质蛋白-1
2011年11月28日 · DMP-1富含天门冬氨酸、丝氨酸和谷氨酸，是一种分泌性磷酸化蛋白，其组成介于骨酸性蛋白和牙本质磷蛋白之间。 诸多研究证实，DMP-1是牙本质形成和矿化的重要的基质蛋白。 1、牙本质基质蛋白-1的表达定位. 1.1 牙本质基质蛋白-1的组织表达定位. 起初，许多学者认为Dmp-1只表达于牙中，是牙本质特异性蛋白，尔后随着研究的逐渐深入，在其他组织中也检测到dmp-1mRNA的表达。 自从在成熟的牙本质细胞中发现dmp-1mRNA的表达后，在成牙本质细胞 …
Dual Functional Roles of Dentin Matrix Protein 1
Dentin matrix protein 1 (DMP1) is a bone- and teeth-specific protein initially identified from mineralized dentin. Here we report that DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin.
Dentin Sialophosphoprotein and Dentin Matrix Protein-1: Two …
DSPP and DMP1 are positive regulators of hard tissue mineralization with DSPP acting on dentin and DMP1 acting on both bone and dentin. Their essential roles for hard tissue development and mineralization in vivo have been analyzed utilizing many knockout and transgenic mouse models (summarized in Table 1 and 2 ).
Functional derivatives of human dentin matrix protein 1 …
2020年3月19日 · In this study, we present a comprehensive structural and functional analysis of 44K and 56K proteins fragments of human DMP1, which correspond to 37K and 57K fragments of DMP1 from rat. We have elaborated and optimized a protocol for the efficient expression and purification of both proteins.
Immunohistochemical analysis of dentin matrix protein 1 (Dmp1 ...
2016年9月10日 · Double-labeling immunoelectron microscopy revealed that phosphorylated C-terminal Dmp1 localized to the canalicular wall in mineralized bone. These findings suggest that C-terminal Dmp1 is phosphorylated within osteocytes and then secreted into the pericanalicular matrix of mineralized bone.
Loss of DMP1 causes rickets and osteomalacia and identifies a
2006年10月8日 · Dentin matrix protein 1 (encoded by DMP1) is highly expressed in osteocytes 4 and, when deleted in mice, results in a hypomineralized bone phenotype 5. We investigated the potential for this gene...
Hematopoietic and stromal DMP1-Cre labeled cells form a unique …
2023年12月16日 · Dentin Matrix Protein 1 (DMP1)-Cre mice have been utilized in bone studies as mature osteoblasts and osteocytes express DMP1. DMP1 has been identified in CXCL12+ cells and an undefined...
DMP1 Binds Specifically to Type I Collagen and Regulates Mineral ...
2018年10月10日 · Dentin matrix protein 1 (DMP1) is one such noncollagenous protein that contains several acidic groups that can bind calcium ions which in turn binds phosphate and initiates the calcification process. In this study, we demonstrate that DMP1 is localized at specific sites on the self-assembled collagen matrix of dentin.