Diacylglycerol O-acyltransferase 2 (DGAT2) is a protein that in humans is encoded by the DGAT2 gene. [5] This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs.

2025年3月28日 · DGAT2 (Diacylglycerol O-Acyltransferase 2) is a Protein Coding gene. Diseases associated with DGAT2 include Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Dgat2 Mutation and Charcot-Marie-Tooth Disease.

DAG与脂酰辅酶A生成甘油三酯（TAG），由二酰基甘油O-酰基转移酶（DGAT）催化。 人类有两种同工酶，称为DGAT1和DGAT2。 甘油三酯虽然毒性较小，但其储存也有严密的程序。 现在认为，甘油三酯在内质网（ER）合成，DGAT催化生成的TAG被释放到内质网膜的脂双层之间。 当TAG积蓄超过某一极限后，新生脂滴从ER膜出芽，释放到胞质溶胶。 脂滴不仅是储存单位，也是代谢单位。 脂滴的分解代谢有两个主要机制：脂解（lipolysis）和 脂肪吞噬 （lipophagy）。 …

DGAT2作为一种甘油酰基转移酶，主要作用机制是催化DAG与脂肪酸酰基反应生成TAG。 DGAT2在脂肪代谢旺盛的组织中的表达水平最高 (如肝脏、白色脂肪组织)，这意味着它在脂质代谢中扮演着十分重要的角色。 DGAT2不仅在TAG合成中起着十分重要的作用，且是动物生存所必需的，DGAT2基因敲出小鼠出生后不久就死亡。 二酯酰甘油酰基转移酶2 (Acyl CoA:Diacylglycerol Acyltransferase 2,DGAT2)是生物体内的一种非常重要的酶。

2024年3月5日 · DGAT2 inhibition blocks triglyceride synthesis in liver and is a promising new approach for the treatment of steatotic liver diseases. Rong et al. show that DGAT2 inhibition has a dual effect: it not only blocks the last step of triglyceride synthesis but also suppresses SREBP-1, the transcriptional activator of lipogenesis in liver.

人体中有两种序列不同源的dgat，分别为dgat1和dgat2。 DGAT1 主要负责脂肪吸收及储存过程中TAG的合成，DGAT2则负责各组织及皮肤基本脂肪的平衡。 前期研究表明，DGAT1敲除的小鼠能保持正常的代谢，并且可以抵抗高脂肪饮食引起的肥胖，而DGAT2敲除的小鼠则由于皮肤 ...

2018年3月21日 · Here, we show that inactivation of DGAT1 or DGAT2 in adult mouse heart results in a moderate suppression of TG synthesis and turnover. Partial inhibition of DGAT activity increases cardiac fatty...

Using co-immunoprecipitation experiments and an in situ proximity ligation assay, we found that DGAT2 interacted with monoacylglycerol acyltransferase (MGAT)-2, an enzyme that catalyzes the synthesis of diacylglycerol. Deletion mutagenesis showed that the interaction with MGAT2 was dependent on the two transmembrane domains of DGAT2.

2019年11月27日 · Nonalcoholic steatohepatitis (NASH) is characterized by the accumulation of hepatocyte triglycerides, the synthesis of which is catalyzed by diacylglycerol acyltransferases (DGATs). Here, we investigate DGAT2 as a potential therapeutic target using an orally administered, selective DGAT2 inhibitor, …

2025年2月8日 · DGAT2, an ER-resident transmembrane domain-containing enzyme, is also found in mitochondria-associated membranes, where its N terminus may promote its association with mitochondria. Review summarizes current knowledge of DGAT1 and DGAT2 enzymes, focusing on new advances since the cloning of their genes, including possible roles in …