2025年3月30日 · LAMP3 (Lysosomal Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with LAMP3 include Mumps and Rem Sleep Behavior Disorder. Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed: 25681212).

2025年2月8日 · The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4. Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma.

LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane. [7] In humans, this protein is almost exclusively found in mature Dendritic cells. While ...

2023年8月8日 · Using fate mapping models, single-cell RNA sequencing and adoptive transfer, we identified a lineage of murine CD16/32 + CD172a + DC3, distinct from DC2, arising from Ly6C + monocyte-DC progenitors (MDPs) through Lyz2 + Ly6C + CD11c − pro-DC3s, whereas DC2s develop from common DC progenitors (CDPs) through CD7 + Ly6C + CD11c + pre-DC2s.

Detailed phenotyping and single‐cell gene expression studies have recently characterized two subsets of cDC2 in human blood, one ‘DC‐like’ with higher expression of CD5, CD1c, HLA‐DQ and IRF4 and the other more ‘monocyte‐like’ showing CD14, CD32, CD36, CD163 and proportionately higher MAFB expression.8, 9 CD14 + CD1c + cells ...

2021年3月4日 · Among their innate immune roles, DCs can recognize and respond to pathogen‐associated and danger‐associated signals. From phagocytosing pathogens, DCs can absorb and present antigens. Activated DCs will then migrate into lymph nodes to interact with T cells and B cells, directly influencing adaptive immunity.

2019年9月30日 · Identification of known DC subtypes in scRNA-seq data. Of the three dendritic cell clusters (C1, C2, and C3), C1 and C2 express all plasmacytoid dendritic cell signature genes (e.g., GZMB and JCHAIN), while C3 shows apparent heterogeneity in DC signature gene expression (e.g., CLEC9A for cDC1 and CD1C for cDC2). It would be interesting to ...

2022年1月13日 · Fate-mapping studies and genetically modified animal models have helped to identify DC progenitors and master transcription factors of the DC lineage, enabling a unifying DC nomenclature that...

2020年10月23日 · DC3 have a mixed cDC2/monocyte gene expression profile and develop from precursors distinct from other DC lineages and monocytes. All human DC subsets express a convergent transcriptional program when they mature in …

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene. [5] DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells.