One of the 20 chemokine receptors identified to date is CXCR2, a G-protein-coupled receptor (GPCR) whose most known ligands are CXCL8 (IL-8) and CXCL1 (GRO-α). In this article we …

In this review, we focus on the contribution of the CXCL12/CXCR4/CXCR7 axis in signaling in tumor/TME cells and we evaluate the possible combined targeting of CXCR4 and CXCR7. …

Coreceptors are necessary for efficient HIV virion attachment that leads to viral fusion and entry. Two such receptors are the G protein-coupled seven transmembrane chemokine receptors …

The CXCR signaling pathway mainly mediates the following effects. We will introduce the cascade through the role of CXCR in different effects: many facts prove that Chemokines regulate the …

Among chemokine receptors, CXCR4 is the most widely expressed, and is involved in numerous physiological and pathological conditions. CXCR4 is expressed by most cells, including …

2020年7月1日 · Here we present the cryo-electron microscopy structures of interleukin-8 (IL-8, also known as CXCL8)-activated human CXC chemokine receptor 2 (CXCR2) in complex with …

2023年7月11日 · Here, we solve the structure of CXCR1 complexed with CXCL8 and cognate G-proteins using cryo-EM, showing the detailed interactions between the receptor, the …

2023年10月21日 · CXCR2 plays diverse and novel roles in cancer, physiology, and viral infection (COVID-19) beyond its widely accepted role in bacterial infections. The pro- or antitumoral …

2015年10月30日 · Both CXCR1 and CXCR2 play a pivotal role in innate immune responses by regulating the recruitment in particular of neutrophils, but also of monocytes, dendritic cells, …

2025年3月30日 · CXCR4 (C-X-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include Whim Syndrome 1 and Macroglobulinemia, …