2025年3月28日 · CLP1 (Cleavage Factor Polyribonucleotide Kinase Subunit 1) is a Protein Coding gene. Diseases associated with CLP1 include Pontocerebellar Hypoplasia, Type 10 and Spinal Muscular Atrophy, Type Ii. Among its related pathways are Processing of Capped Intronless Pre-mRNA and Processing of Capped Intron-Containing Pre-mRNA.

This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing Endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia ...

2025年2月9日 · This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation.

2013年3月10日 · Here we generated kinase-dead Clp1 (Clp1K/K ) mice that show a progressive loss of spinal motor neurons associated with axonal degeneration in the peripheral nerves and denervation of...

2023年12月1日 · Clp1, a conserved protein, is proposed to interlink 3′-end processing, transcriptional elongation and transcription termination. However, experimental evidence defining the precise roles played by Clp1, its interacting partners from other subunits and information about its exact mechanism of action during pre-mRNA processing is lacking.

2022年6月1日 · In short, CLP1 may play a non-negligible role in the onset and development of RA by altering immune cell infiltration, and it is predicted to represent a novel target for RA clinical diagnosis and therapy. Keywords: CLP1; RNA modification; diagnostic biomarkers; gene expression profile data; rheumatoid arthritis.

2023年3月29日 · The CLP1 gene encodes a component of the tRNA endonuclease complex (TSEN), which removes introns from pre-tRNA transcripts. CLP1 is a multifunctional kinase implicated in tRNA, mRNA, and siRNA maturation (summary by Karaca et …

2014年4月4日 · From a cohort of over 2000 consanguineous families with childhood neurological disease, we identified a founder mutation in four independent pedigrees in cleavage and polyadenylation factor I subunit (CLP1). CLP1 is a multifunctional kinase implicated in tRNA, mRNA and siRNA maturation.

2014年4月24日 · From a cohort of more than 2,000 consanguineous families with childhood neurological disease, we identified a founder mutation in four independent pedigrees in cleavage and polyadenylation factor I subunit 1 (CLP1). CLP1 is a multifunctional kinase implicated in tRNA, mRNA, and siRNA maturation.

2023年8月22日 · Cleavage factor polyribonucleotide kinase subunit 1 (Clp1) is an enzyme with polynucleotide kinase (PNK) activity, which transfers the phosphate group of ATP to the 5′ end of RNA (Weitzer and Martinez 2007).