The name claudin comes from Latin word claudere ("to close"), suggesting the barrier role of these proteins.

Claudin-1是一种新型靶点，具有独特的作用机制，在肝纤维化和纤维化驱动型肝胆癌的病理中发挥关键作用。 Claudin1靶向药物目前有ALE-F02处于1期临床研究、ALE-C04处于临床前研究。

Claudin家族. Claudins是一类存在于上皮和内皮中的整合素膜蛋白，是紧密连接结构和功能的骨架蛋白，位于相邻细胞间隙顶侧，与其他结构蛋白和信号蛋白协同作用，主要功能有细胞间黏附 …

2024年9月9日 · 用于 claudin 靶向治疗的单克隆抗体在初始肿瘤学临床试验中显示出前景 （5）。只要蛋白质可及，抗体就以高亲和力和高特异性与靶蛋白结合。针对 claudin 家族的抗体在肿 …

目前认为，跨膜蛋白中起主要作用的是Occludin和Claudin，尤其以Claudin的作用最为重要，这是形成紧密连接功能的主要蛋白 [1]。 Claudin主要作用是维持细胞间的物理屏障功能及细胞极性。

2018年10月25日 · Claudins are cell–cell adhesion molecules located at the tight junctions (TJs) between cells in epithelial cell sheets. The claudin family in mammals consists of 27 four …

2024年3月19日 · In this Review, we highlight the biological rationale and explore the clinical activity of therapies that target claudin 18.2 in patients with advanced-stage gastric cancer and …

Claudins are a family of nearly two dozen transmembrane proteins that are a key part of the tight junction barrier that regulates solute movement across polarized epithelia. Claudin family …

Claudin proteins are a class of transmembrane proteins involved in the formation of tight junctions (TJ), characterized by four transmembrane domains and two extracellular loops. Abnormal …

2019年1月29日 · At the blood-brain barrier, claudin-5 is the most enriched tight junction protein and its dysfunction has been implicated in neurodegenerative disorders such as Alzheimer's …