2014年5月6日 · Chromone (1) (4H-chromen-4-one, 4H-1-benzopyran-4-one) is an important class of oxygen-containing heterocyclic compounds with a benzoannelated γ-pyrone ring and they are part of the flavonoid family (Fig. 1). The chromone and related compounds are widespread in the plant kingdom from algae to conifers.

2011年7月7日 · Chromone 1 was prepared by condensation of the 2′-hydroxyacetophenone with ethyl formate in the presence of sodium hydride in THF followed by dehydration of the resulting chroman-3-ol with p-toluenesulfonic acid (PTSA) in refluxing benzene (Scheme 1). 46 The condensation of 2′-hydroxy-4′-methoxyacetophenone with ethyl methanoate in the presence of sodium in diethyl ether followed by ...

2022年1月1日 · Chromones is a family of oxygen heterocyclic compounds whose synthetic versatility and broad spectrum of bioactive properties has been widely reported…

2024年12月19日 · In 2022, Yu and collaborators successfully developed an iodine-promoted tandem vinyl α-C-H bond phosphorothiolation and chromone cyclization reaction involving o-hydroxyaryl enaminones 1 and P(O)SH compounds 49. This method facilitates the construction of a series of highly valuable S-3-chromone phosphorothioates 50 (Scheme 24) [89]. Notably ...

2020年12月1日 · Chromone and flavone are both central backbones of natural products and clinical medicines. Synthesis of diversely functionalized chromones and flavones constitutes significant research contents of the modern synthetic science because abundant molecular libraries of such types are crucial in providing candidate compounds for the discovery of ...

The chromone motif features in a number of natural products: especially abundant are the flavones (2-arylchromones) and isoflavones (3-arylchromones). A range of biological activities are exhibited by both synthetic and naturally occurring chromones; the antimicrobial activity <2005JAA343> , biochemistry <2005CJB433> and recent advances in ...

2022年9月5日 · The chromone (Scheme 17) 55 was formed by condensation of 2-hydroxy acetophenone 53 with N,N-dimethylformamide dimethyl acetal 54 under MW irradiation and in situ cyclization using HCl [37].

Details of diverse biological activities of chromone derviatives, such as anti-cancer, antimicrobial, anti-viral, anti-inflammatory, antioxidant, as Monoamine Oxidase-B (MAO-B) inhibitors, anti-Alzheimer’s agents, anti-diabetic agents, having antihistaminic potential, and acting as antiplatelet agents, are discussed.

2021年4月1日 · A series of chromone linked [1,2,3]-triazoles were designed based on literature followed by in silico studies. The in silico studies indicated good docking score for (2E)-(1R-1,2,3-triazol-4-yl)methyl 3-(6-methyl-4-oxo-4H-chromen-3-yl)acrylate derivatives when docked into the Human Estrogen Receptor Alpha Ligand-Binding Domain (PDB ID: 1XP6).

2023年11月1日 · A series of chromone-thiazolidine-2,4-dione derivatives (e1 ∼ 28) were synthesized and screened for their α-glucosidase inhibitory. All synthetic derivatives presented excellent α-glucosidase inhibitory with IC 50 values ranging from 2.40 ± 0.11 to 5.66 ± 0.15 μM, comparing to positive control acarbose (IC 50 value: 640.57 ± 5.13 μM).