2025年3月30日 · CHRNA6 (Cholinergic Receptor Nicotinic Alpha 6 Subunit) is a Protein Coding gene. Diseases associated with CHRNA6 include Alcohol Dependence and Dystonia 6, Torsion. Among its related pathways are Postsynaptic nicotinic acetylcholine receptors and Transmission across Chemical Synapses.

编码的蛋白质是神经元烟碱型乙酰胆碱受体的亚基，可介导多巴胺能神经传递并被乙酰胆碱和外源性尼古丁激活。 已观察到该基因的可变剪接转录物变体。 该基因的单核苷酸多态性与尼古丁和酒精依赖有关。 [RefSeq 提供，2010 年 12 月] This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission.

Chrna6 has a cellular expression signature for retinal ganglion cells with high correlation to Thy1, a known marker. Immunofluorescence confirms this gene is preferentially expressed by RGCs in the young and adult mouse retina and expression is reduced in glaucoma.

The CHRNA6 gene codes for the α6 nicotinic receptor subunit that is found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine -releasing neurons in the midbrain, [ 6 ] [ 7 ] and dopamine release following activation of ...

2024年9月26日 · Our findings indicate that the CHRNA6 may act as a predictive indicator for SCLC patients receiving immunotherapy. The study also uncovers the aberrant expression of CHRNA6 in a range of human cancers and its potential roles in immunology and prognosis, offering novel perspectives for tailored cance …

Our findings indicate that the CHRNA6 may act as a predictive indicator for SCLC patients receiving immunotherapy. The study also uncovers the aberrant expression of CHRNA6 in a range of human cancers and its potential roles in immunology and prognosis, offering novel perspectives for tailored cancer therapies.

CHRNA6 may be associated with immune infiltration in LUSC and affects patient prognosis and immunotherapeutic response by regulating immune cells and immune pathways. In addition, adavosertib may be a potential drug for the treatment of LUSC.

2025年2月8日 · Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within membrane depolarization and regulation of dopamine secretion. Part of acetylcholine-gated channel complex.

Clinical resource with information about CHRNA6, Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2010年5月18日 · CHRNA6 is 1 of several subunits that can be incorporated into 5-subunit nicotinic acetylcholine receptors (nAChRs), which function as ligand-gated ion channels involved in fast synaptic transmission (Ebihara et al., 2002).