2025年3月30日 · CHRNA2 (Cholinergic Receptor Nicotinic Alpha 2 Subunit) is a Protein Coding gene. Diseases associated with CHRNA2 include Epilepsy, Nocturnal Frontal Lobe, 4 and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. Among its related pathways are Postsynaptic nicotinic acetylcholine receptors and Transmission across Chemical Synapses.

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene. [5] [6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

In this opinion article we highlight the recently discovered beige-selective signaling between acetylcholine from immune cells and cholinergic receptor nicotinic alpha 2 subunit (CHRNA2) in activated beige adipocytes.

2023年10月1日 · However, the study discuss three hypotheses regarding the involvement of CHRNA2 in cannabis use disorder: (1) cannabis substances may directly interact with α2-containing nAChRs; (2) cannabis could indirectly impact these receptors by affecting neurotransmitter release, particularly dopamine, which is …

These results reveal a beige-selective immune-adipose interaction mediated through CHRNA2 and identify a novel function of nicotinic acetylcholine receptors in energy metabolism. In our analysis, we found one pair of SNPs in CHRNA1 and CHRNA7, plus one pair of SNPs in CHRNA2 and CHRNA3 reached corrected significance in tests for GxG interaction.

烟碱型乙酰胆碱受体 (nAChRs) 是由 alpha 和 beta 亚基的五聚体排列形成的配体门控离子通道，可产生不同的肌肉和神经元受体。 神经元受体遍布周围和中枢神经系统，它们参与快速突触传递。 该基因编码在大脑中广泛表达的α亚基。 拟议的 nAChR 亚基结构是一个保守的 N 末端细胞外结构域，后跟三个保守的跨膜结构域、一个可变的细胞质环、第四个保守的跨膜结构域和一个短的 C 末端细胞外区域。 该基因的突变导致常染色体显性遗传性夜间额叶癫痫 4 型。 该基因的单核苷 …

We recently identified a new beige fat regulatory pathway mediated via the nicotinic acetylcholine receptor subunit CHRNA2. Here, we generated fat-specific Chrna 2 KO mice and observed thermogenic defects in cold and metabolic dysfunction upon dietary challenges caused by adipocyte-autonomous regulation in vivo.

CHRNA2 signaling regulates both canonical and glycolytic beige fat function. Upon cold exposure, acetylcholine secreted from cholinergic macrophages within the subcutaneous fat depot activates CHRNA2 signaling in beige adipocytes. CHRNA2 signaling mediates thermogenesis through both uncoupling protein 1 (UCP1)- and creatine-dependent pathways.

The CHRNA2 gene provides instructions for making one part (subunit) of a larger protein called a neuronal nicotinic acetylcholine receptor (nAChR). Learn about this gene and related health conditions.

gic receptor nicotinic alpha 2 subunit (CHRNA2) in activated beige adipocytes. We present our current knowledge of how this previously unrecognized adipose non-neuronal cholinergic signaling pathway mediates beige thermoregulation, and discuss its impact on whole-body fitness and its therapeutic potential as a