2025年3月30日 · CDK11B (Cyclin Dependent Kinase 11B) is a Protein Coding gene. Diseases associated with CDK11B include Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations and Neuroblastoma. Among its related pathways are Loss of Nlp from mitotic centrosomes and Cell Cycle, Mitotic.

2025年2月9日 · CDK11 facilitates centromeric transcription to maintain centromeric cohesion during mitosis. CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples. Therapeutic potential of CDK11 in cancer. CDK11 negatively regulates Wnt/beta-catenin signaling in the endosomal compartment by affecting microtubule stability.

该基因编码丝氨酸/苏氨酸蛋白激酶家族的成员。 已知该激酶家族的成员对真核细胞周期控制至关重要。 由于片段重复，该基因与邻近基因具有非常高的序列同一性。 这两个基因在神经母细胞瘤中经常被删除或改变。 该基因编码的蛋白激酶可被半胱天冬酶切割，并可能在细胞凋亡中发挥作用。 可变剪接导致多个转录本变体。 [RefSeq 提供，2014 年 4 月] This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be …

Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel. Liu X, et al. Mol Cancer Ther, 2016 Jul. PMID 27207777, Free PMC Article. What's a GeneRIF?

2024年9月7日 · Recent work has showed that cyclin-dependent kinase (CDK)11 regulates spliceosome activation via the phosphorylation of SF3B1, a core spliceosome component. Thus, CDK11 arises as a major coordinator of gene expression in metazoans due to its role in the rate-limiting step of pre-mRNA splicing.

2022年9月14日 · Inhibition of CDK11 prevents spliceosomal transition from the precatalytic complex B to the activated complex B act and leads to widespread intron retention and accumulation of non-functional...

Predicted to enable ATP binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of cell growth; and regulation of mRNA processing.

2024年3月5日 · Clinical resource with information about CDK11B, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

CDK11B的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基因编码的丝氨酸/苏氨酸蛋白激酶家族的一个成员。 此激酶家族成员是已知的真核细胞周期控制是必不可少的。 由于一个段重复，此基因股与相邻的基因非常高的序列同一性。 这两个基因，频繁删除或在神经母细胞瘤改变。 由该基因编码的蛋白激酶可以通过半胱天冬被裂解，并且可以在细胞凋亡的作用。 选择性剪接结果在多个抄本变形。 [由RefSeq的，2014年4月提供]

Increasing evidence has suggested the crucial role cyclin-dependent kinases (CDKs) in the biology of hepatocellular carcinoma (HCC), a lethal malignancy with high morbidity and mortality. Hence, this study explored the modulatory effect of the putative cyclin-dependent kinase 11B (CDK11B)-mediated u …