CD6-targeted antibody-drug conjugate as a new therapeutic
2023年8月12日 · We prepared a CD6-targeted antibody-drug conjugate (CD6-ADC) by conjugating monomethyl auristatin E (MMAE), an FDA-approved mitotic toxin, to a high-affinity …
CD6 as a Cell Surface Receptor and As a Target for Regulating …
CD6 has been exploited as a drug target as its expression is restricted, primarily to T cells, it has a well characterised cell surface ligand, CD166 and regulates T cell activation through a long …
CD6 - Wikipedia
CD6 (C luster of D ifferentiation 6) is a human protein encoded by the CD6 gene. [5][6] This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other …
CD6 in Human Disease - MDPI
2025年2月13日 · CD6 is a risk gene for multiple autoimmune diseases, possibly related to its numerous roles in regulating CD4+T-cell responses. Additionally, CD6 is a potential target for …
Structures of CD6 and Its Ligand CD166 Give Insight into Their ...
CD6 is a transmembrane protein with an extracellular region containing three scavenger receptor cysteine rich (SRCR) domains. The membrane proximal domain of CD6 binds the N-terminal …
Clinical and experimental evidence for targeting CD6 in immune …
2018年5月1日 · CD6 is a lymphocyte receptor selectively expressed on most T cells and some B cells. CD6 is involved in cell-to-cell contacts and modulation of adaptive immune responses. …
CD6 Gene - GeneCards | CD6 Protein | CD6 Antibody
2025年3月28日 · CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include Multiple Sclerosis and Microsporidiosis. Gene Ontology (GO) annotations related to …
CD6 as a Therapeutic Target in Autoimmune Diseases ... - Springer
2013年4月9日 · The transmembrane surface glycoprotein CD6 was one of the first antigens identified on T lymphocytes. The recognition of its involvement in T-cell signaling processes …
CD6 in Human Disease - PubMed
2025年2月13日 · CD6 is a risk gene for multiple autoimmune diseases, possibly related to its numerous roles in regulating CD4+T-cell responses. Additionally, CD6 is a potential target for …
CD6蛋白与细胞信号传导—艾普蒂生物 - 搜狐
2024年9月13日 · 本文将详细探讨CD6蛋白的结构与功能、 其在细胞信号传导中的作用机制以及其生物学意义。 1. CD6蛋白的结构与功能. 结构特征：CD6是一种跨膜糖蛋白，属于免疫球蛋白 …