CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). [9] CD45 has been shown to be an essential regulator of T-and B-cell antigen receptor signalling.

4 天之前 · Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). CD45 is positive in nearly all cases and it is an important marker together with other B cell markers (CD20, PAX5, CD19, CD79a, CD75, OCT2 and BOB1) in differentiating classic Hodgkin lymphoma (CHL) …

CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells.

CD45 is a type of protein called a tyrosine phosphatase. It plays a critical role in regulating cell signaling pathways that are important for immune cell activation and differentiation. How is CD45 used in pathology?

CD45 is an essential protein on the surface of cells of the haematological and immunological systems. It has been used as a diagnostic tool to identify cells of haematological origin, but its function and structure are not widely understood. This review aims to …

2025年3月11日 · Explore the function of CD45 in immune regulation, its role in T-cell signaling, and its diagnostic relevance in hematology. CD45 is a crucial protein on most immune cells, functioning as a phosphatase that regulates signaling pathways controlling immune responses.

CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and …

CD45 activates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts.

CD45 is a transmembrane glycoprotein that is located on the surface of all leukocytes and modulates both innate and adaptive immune system functions. In a recent study, inflammation modulated the CD45 expression in leukocytes, but the …

2010年1月1日 · CD45 (also known as leukocyte common antigen (LCA), EC 3.1.3.48, T200, Ly5, PTPRC, and B220) constitutes the first and prototypic receptor-like protein tyrosine phosphatase (RPTP). This chapter briefly summarizes the current understanding of the structure, function, and regulation of this key phosphatase.