The interaction and binding of ligand-receptor HA-CD44 regulate the downstream cytoskeleton pathways involve in cell survival or cell death. Thus, targeting HA, CD44 (variant and …

CD44 and receptor for HA-mediated motility (RHAMM) are the two main HA-receptors whose biological functions in human and murine inflammations and tumor cells have been …

The CD44 structure of normal cells is distinct from that of cancer cells because pathological conditions promote alternate splicing and post translational modifications to produce …

2018年5月10日 · Here, we review current data on the structural and functional properties of CD44, the known roles for CD44 in tumorigencity, the regulation of CD44 expression, and the …

In this study, we have established quantitative relationships between CD44 expression in differently polarized macrophages (M0, M1, and M2-polarized THP-1 human macrophages) …

2020年10月6日 · Our results revealed that an ER-CD44-HA signaling circuit that mediates robust compensatory activation of the Src-ERK signaling cascade may contribute to the development …

2017年5月1日 · HA is used by several investigators as a vehicle to transport anticancer drugs for at least three reasons. First, HA binds CD44 variants. Second, HA-drug conjugate is …

2023年10月31日 · Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of …

2021年9月3日 · There is ample evidence showing that both CD44 and HA are abundantly expressed at sites of tumor attachment and binding of HA to the extracellular domain of CD44 …

Understanding how CD44 and HA regulate inflammation in atherogenesis is key in determining the utility of the CD44-HA axis as a therapeutic target to halt disease and potentially promote …