Mar 28, 2025 · CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex) is a Protein Coding gene. Diseases associated with CD3E include Immunodeficiency 18 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are Immune response NFAT in immune response and TCR Signaling (Qiagen).

Mar 8, 2025 · Title: Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient. Biallelic Form of a Known CD3E Mutation in a Patient with Severe Combined Immunodeficiency.

Aug 20, 2020 · Collectively, CD3ε is a built-in multifunctional signal tuner, and increasing CD3 diversity represents a strategy to design next-generation CAR. Keywords: CAR-T therapy; Csk; ITAM; T cell receptor; TCR; cancer; cell persistence; cytokine release; p85; phosphorylation pattern; quantitative mass spectrometry. Copyright © 2020 Elsevier Inc.

In this study, we examined the role of CD3ε ITAM-mediated signals in T cell development by genetically reconstituting CD3ε-deficient mice with transgenes encoding either wild-type or ITAM-mutant (signaling defective) forms of the protein.

Apr 12, 2024 · An inhibitory ligand acts directly on CD3e to regulate T cell activation, and disruption of the interaction boosts tumor-specific T cell cytotoxicity to limit tumor growth.

CD3E is a prognostic marker in Breast invasive carcinoma, Cervical squamous cell carcinoma and endocervical adenocarcinoma, Head and neck squamous cell carcinoma

Jul 29, 2020 · Collectively, CD3ε is a built-in multifunctional signal tuner, and increasing CD3 diversity represents a strategy to design next-generation CAR.

Dec 27, 2024 · Clinical resource with information about CD3E, Immunodeficiency 18, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in …

Jan 29, 2014 · CD3E-specific antibody treatment induced remission in nonobese diabetic (NOD) Cd28 (186760)-null mice that were devoid of such regulatory cells. Remission of diabetes was abrogated by coadministration of a neutralizing TGF-beta (190180)-specific antibody.