CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms. [6] CD37 controls both humoral [11] …

2025年3月28日 · CD37 (CD37 Molecule) is a Protein Coding gene. Diseases associated with CD37 include Mantle Cell Lymphoma and Diffuse Large B-Cell Lymphoma. Among its related pathways is TYROBP causal network in microglia. An important paralog of this gene is CD82.

2024年5月15日 · We repurpose the anti-lymphoma CD37CAR for the treatment of AML and show that CD37CAR T cells specifically kill AML cells, secrete proinflammatory cytokines, and control cancer progression in vivo. Importantly, CD37CAR T cells display no toxicity toward hematopoietic stem cells. Thus, CD37 is a promising and safe CAR T cell AML target.

CD37 is a tetraspanin expressed prominently on the surface of B cells. It is an attractive molecular target exploited in the immunotherapy of B cell-derived lymphomas and leukemia. Currently, several monoclonal antibodies targeting CD37 as well as chimeric antigen receptor-based immunotherapies are being developed and investigated in clinical ...

cd37 分子： 由该基因编码的蛋白质是跨膜 4 超家族的成员，也称为四跨膜蛋白家族。 这些成员中的大多数是细胞表面蛋白，其特征在于存在四个疏水结构域。

2012年5月15日 · The signaling role of CD37 in normal and transformed B cells has not been characterized. Our extensive studies have identified a unique function of CD37 as a death receptor in B cells. We have demonstrated that CD37 is a tetraspanin that can directly mediate dual signal transduction through the C- and N-terminal domain.

2020年4月28日 · DuoHexaBody-CD37, a bispecific CD37 antibody with the E430G hexamerization-enhancing mutation targeting two non-overlapping epitopes on CD37 (biparatopic), demonstrated potent and superior...

2020年5月29日 · Patients with high CD37 expression had shorter overall survival (OS) and disease-free survival (DFS). Pathway analysis data showed that CD37 is involved in DNA replication, RNA transport, Salmonella infection, ribonucleoprotein complex biogenesis, cell cycle phase transition and so on.

CD37，即分化抗原37，别名T细胞分化抗原、Leu-22等。 它是一种由CD37基因编码的糖蛋白，主要表达在多种免疫细胞表面，包括B细胞、T细胞、自然杀伤(NK)细胞等。

2025年2月8日 · CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma. Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML).