CD28主要作为“第二信号” （与靶细胞表面的B7-1/ B7-2结合） 降低有效活化T细胞所需的阈值，强化激活T细胞的“第一信号” （T细胞受体（TCR）- CD3复合物对靶细胞的MHC-多肽识别和结 …

CD28 serves as a receptor for CD80 (B7.1) and CD86 (B7.2), proteins found on antigen-presenting cells (APCs). CD28 is the only B7 receptor consistently expressed on naive T cells. …

The CD28 ligands CD80 and CD86 diverge in their expression patterns, multimeric states, and functionality, adding another layer of complexity to the regulation of CD28 signaling. CD80 is …

1997年2月3日 · The structurally related T cell surface molecules CD28 and CTLA-4 interact with cell surface ligands CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells (APC) and …

CD80 is the ligand for the proteins CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) found on the surface of T …

This article reviews the CD28/CTLA4 and CD80/CD86 families, and outlines the functional outcomes and biochemical signaling pathways recruited after CD28 ligation. T cell stimulation …

2001年11月19日 · CD28 is a homodimeric type 1 transmembrane protein that is a member of the immunoglobulin (Ig) superfamily and has a single Ig-like domain. CD28 interacts with CD80 …

The primary ligands, B7-1 (CD80) and B7-2 (CD86), in turn can bind multiple receptors (including CTLA4) (Schildberg et al., 2016 in this issue). In this review, we summarize the current …

2018年7月31日 · The simulations predict a mechanism of CD28 movement, according to which CD28-CD80 complexes passively follow TCR-pMHC microclusters. However, the …

2022年4月4日 · To address this, here we utilize directed evolution to engineer a CD80 IgV domain with increased PD-L1 affinity and fuse this to an immunoglobulin Fc domain, creating a …