2024年1月4日 · Using pharmacological inhibitors and neutralizing antibodies, CD204+ M2-like TAMs-secreted TNFα was found to upregulate miR-210 through NF-κB/HIF-1α signaling. Bioinformatics analysis showed netrin-4 (NTN4) as a potential target of miR-210 to suppress gastric cancer cell migration.

2017年5月11日 · CD163 and CD204-positive macrophages are positively correlated with the histological gradient of malignancy in human ovarian tumors 8 and thus CD163 and CD204 are useful markers for activation...

2020年5月8日 · Here, we evaluated the association between the amount of intraepithelial and stromal TIIC, their ratios and PD‐L1 expression level with thymic carcinomas through IHC, and identified B cells (CD20 +) and M2 macrophage (CD204 +) as the prognostic factors.

CD8, CD20 and CD204 positive TIIC in stroma were identified as possible better prognostic biomarkers, considering the heterogeneity of other biomarkers. The present study paves the way for exploring strategies of combination immunotherapy targeting B cell …

2021年11月18日 · Macrophages can be classified into M1 and M2 subtypes, and CD204 is a marker of M2-like macrophages and plays important roles in the tumor microenvironment by inhibiting anti-tumor immune ...

2010年10月1日 · Recent studies have reported strong expression of CD204 by M2 macrophages, and using CD204 (scavenger receptor class A) as a marker has revealed that invasion by CD204-positive macrophages is related to tumor progression and outcome in glioma, ovarian epithelial tumors, and pancreatic cancer.11, 12, 13, 18 CD204 is the prototypic member of an ex...

2018年2月2日 · A higher density of tumor‐infiltrating CD 204 + M2 macrophages was significantly associated with shorter disease‐free survival, although no other tumor‐infiltrating immune cells were prognostic, including CD 4 +, CD 8 +, FOXP 3 +, …

2025年3月12日 · M2-like TAMs activated by these cytokines engage the STAT6 signaling pathway, upregulate expression of mannose receptor-1 (CD206) and scavenger receptors (CD204, CD163), and secrete substantial amounts of anti-inflammatory factors, pro-angiogenic cytokines, and transforming growth factor-beta (TGF-β), …

2024年1月4日 · Using pharmacological inhibitors and neutralizing antibodies, CD204 + M2-like TAMs-secreted TNFα was found to upregulate miR-210 through NF-κB/HIF-1α signaling. Bioinformatics analysis showed netrin-4 (NTN4) as a potential target of miR-210 to suppress gastric cancer cell migration.

A higher density of tumor-infiltrating CD204 + M2 macrophages was significantly associated with shorter disease-free survival, although no other tumor-infiltrating immune cells were prognostic, including CD4 + , CD8 + , FOXP3 + , and PD-1 + lymphocytes and CD68 + macrophages.