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CB-13 (CRA13, SAB-378) [1] is a cannabinoid drug, which acts as a potent agonist at both the CB 1 and CB 2 receptors, but has poor blood–brain barrier penetration, and so produces only peripheral effects at low doses, with symptoms of central effects such as catalepsy only appearing at much higher dose ranges.

Brooklyn Community Board 13 Staff and Board Members published this Service Directory to assist our residents and businesses in locating services within the community. It contains helpful and important numbers for local and citywide agencies.

Queens Community Board 13 holds General Board Meetings and Committee Meetings that address items of concern to the community. Board actions and decisions are advisory. The Community Board frequently calls public hearings on land use matters and other major issues to give the community an opportunity to express their opinions.

See detailed specifications and technical data for Caterpillar CB13 manufactured in 2019 - 2025. Get more in-depth insight with Caterpillar CB13 specifications on LECTURA Specs.

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2022年8月8日 · CB-13 (0.3, 1, 3, 10 mg/kg i.p.) reduced CFA-induced mechanical allodynia in a dose-dependent manner that was equipotent in both males (A,C) and females (B,D). CB-13’s anti-allodynic effects are long-lasting in males (E) and females (F) (BL = baseline, CFA = 24 h post-CFA, before treatment with vehicle or CB-13).

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CB-13 is a dual agonist of the CB 1 (IC 50 = 15 nM) and CB 2 (IC 50 = 98 nM) receptors. 1 In rats, oral CB-13 (3 mg/kg) potently blocks CB 1-dependent neuropathic mechanical hyperalgesia, shows limited brain penetration, and exhibits good oral bioavailability. 1 CB-13 does not possess genotoxic potential, as indicated by negative results in ...

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