Caspase-8 hampers pro-inflammatory gene expression induced by the cytosolic RNA sensor retinoic acid-inducible gene I (RIG-I) through cleavage of RIPK1, which is recruited to a complex of RIG-I and its adapter molecule mitochondrial antiviral signaling protein (MAVS) on mitochondria .

2019年11月20日 · Caspase-8 is the initiator caspase of extrinsic apoptosis 1, 2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic...

Caspase-8-dependent cleavage and activation of the NLRP3 trigger the assembly of the inflammasome complex to enable cytokine release. Conversely, caspase-8 activation can inhibit other signaling platforms, such as the necrosome, which is composed of receptor-interaction protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3).

In this review, we discuss the emerging crosstalk between cell death and innate immune cell inflammatory signalling, particularly focusing on novel non-apoptotic functions of caspase-8. We also highlight the growing number of autoinflammatory diseases that are associated with enhanced inflammasome function.

2022年1月21日 · Caspase-8 is an initiator of death receptor-induced apoptosis and an inhibitor of RIPK3-MLKL-dependent necroptosis. In addition, caspase-8 has been implicated in...

Caspase-8 is a cysteine - aspartate specific protease that classically triggers the extrinsic apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like FAS, TRAIL-R and TNF-R.

Integral in the regulation and initiation of death receptor-mediated activation of programmed cell death is the aspartate-specific cysteine protease (caspase)-8. This review describes the role of caspase-8 in the initiation of extrinsic apoptosis execution and the mechanism by which caspase-8 inhibits necroptosis.

Initially discovered as an initiator protease in apoptosis mediated by death receptors, caspase-8 is now known to have an apparently confounding opposing effect in securing cell survival. It is required to allow mouse embryo survival, and the survival of hematopoietic cells during their development and activation.

Caspase-8 is the initiator caspase of extrinsic apoptosis 1,2 and inhibits necroptosis mediated by RIPK3 and MLKL. Accordingly, caspase-8 deficiency in mice causes embryonic lethality³, which can be rescued by deletion of either Ripk3 or Mlkl^4-6.

Caspase 8 is a cysteine protease that initiates apoptotic signaling via the extrinsic pathway and is differentially expressed in the peripheral immune system of MS patients (Comabella and Martin, 2007).