A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents.

Specifically, this study examined the effects of the cholinergic agonist carbachol and agents that increase cAMP [secretin and 8-bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP)] on zymogen activation (trypsin and chymotrypsin), enzyme secretion, and cellular injury in isolated pancreatic acini.

2013年2月1日 · The agonists carbachol (CCh) and bradykinin (BK) and 54 mM KCl (high K+) were among the most potent stimulants of cyclic AMP (cAMP) production in cultured rat sympathetic neurons, measured with the use of a high-fidelity assay developed for small samples. The rise in cAMP evoked by CCh (through musc …

Carbachol (1 m M) and oxotremorine-M (1 m M) brought about net stimulation (above 100% of control) of cyclic AMP synthesis during 2 min incubations. The stimulatory components disappeared after the density of receptors had been lowered with oxyphenonium mustard.

1991年7月15日 · We now report that muscarinic agonist carbachol induces in dose-dependent enhancement of basal, forskolin- and vasoactive intestinal peptide (VIP) stimulated cAMP levels in SH-SY5Y cells. The enhancement of cAMP levels appears to require calmodulin activation, reflecting cross-talk between the two signal transduction pathways.

A depolarizing concentration (56 mM) of KCl produces a 24-h delay in the induction of TH elicited by RO 20-1724, without affecting the concomitant elevation of cyclic AMP produced by the PDE inhibitor. Furthermore, 56 mM-KCl inhibits the induction of TH elicited by 8-bromo cyclic AMP.

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2005年6月13日 · Carbachol is a direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery.

Carbamoylcholine chloride is a nAChR and mAchR receptor agonist with K. values of 10-10,000 nM. Carbamoylcholine chloride can be used to study nAChR and mAchR -mediated responses, including smooth muscle contraction, intestinal motility, and neural signaling. Room temperature in continental US; may vary elsewhere.

2016年10月5日 · The effects of cyclic AMP on contraction and Ca (2+)-activated K+ currents induced by carbachol (CCh), caffeine and inositol 1,4,5-trisphosphate (InsP3) were examined in intact and skinned smooth muscle fibres and in whole-cell voltage-clamped smooth muscle cells of the rat stomach.