2025年3月30日 · CAPN10 (Calpain 10) is a Protein Coding gene. Diseases associated with CAPN10 include Type 1 Diabetes Mellitus 2 and Polycystic Ovary Syndrome. Among its related pathways are DREAM Repression and Dynorphin Expression and …

It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It therefore cannot heterodimerize with the small subunit. It is similar in organization to calpains 5 and 6.

CAPN10, which encodes the cysteine protease calpain 10, was the first type 2 diabetes mellitus (T2DM) susceptibility gene identified through a genome-wide scan followed by positional cloning. A haplotype combination comprising three intronic CAPN10 single-nucleotide polymorphisms (UCSNP-43, -19, and …

2025年2月10日 · CAPN10 alleles are associated with polycystic ovary syndrome; We show that the diabetes gene calpain-10 (CAPN10) plays a role in atherosclerosis, insulin sensitivity and insulin secretion in a population enriched for atherosclerosis and insulin resistance. polymorphism influences glucose metabolism in human fat cells

It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region.

CAPN10 is ubiquitously distributed, and its cellular localization is dynamic. When localized to the mitochondria, it mediates mitochondrial dysfunction by cleaving Complex I subunits and promotes mitochondrial permeability transition. CAPN10 is also involved in GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes.

2025年1月4日 · It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region.

Calpain-10 (CAPN10) is the first diabetes gene to be identified through a genome scan. Many investigators, but not all, have subsequently found associations between CAPN10 polymorphism and type 2 diabetes (T2D) as well as insulin action, insulin secretion, aspects of adipocyte biology and microvascu …

It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region.

The CAPN10 gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family. The 672 amino-acid protein shares 81.7% identity with the mouse ortholog. CAPN10 was expressed as major and minor transcripts of 2.7 and 4.0 kb, respectively, present at low levels in all adult and fetal tissues examined, with slightly higher ...