A calpain (/ ˈkælpeɪn /; [1] EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium -dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database.

细胞中钙蛋白酶活性受到Ca2+和钙蛋白酶抑制蛋白（calpastatin）、钙蛋白酶激活蛋白（calpain activator）的调节，其中calpain activator是calpain的正调节因子。 提高Ca2+浓度，钙蛋白酶的活性增强，Ca2+浓度进一步提高将导致构象变化而表现蛋白水解酶活性。

2021年5月1日 · Calpains are calcium-dependent cysteine proteases. The members of the calpain family can have a classical or a non-classical structural organisation. Calpains as proteases require a number of mechanisms to control their activity from spatio-temporal modifications of expression to changes in molecular conformation.

The calpain system originally comprised three molecules: two Ca2+-dependent proteases, mu-calpain and m-calpain, and a third polypeptide, calpastatin, whose only known function is to inhibit the two calpains.

2021年8月20日 · Calpain 是一类在多种生物体内广泛表达的，在中性 pH 条件下发挥活性的钙依赖蛋白酶。它和诸如局部脑缺血、神经退行性疾病等病理过程等密切相关。 它和诸如局部脑缺血、神经退行性疾病等病理过程等密切相关。

Calpain is calcium-activated protease which exists as an inactive proenzyme in the cytosol. When intracellular calcium level is overloaded, it triggers to convert the proenzyme to its active form. Activated calpain then cleaves cytoplasmic and nuclear substrates, leading to apoptosis. References. 1. Kerr JF, Wyllie AH, Currie AR.

Calpain is a Ca2+-regulated cytosolic cysteine protease that exists mainly in two isoforms and mediates crucial cellular functions, including rearrangement of cytoskeletal proteins, transport of the glucose transporter GLUT4, and protein cleavage to …

2012年1月1日 · Calpain is an intracellular Ca 2+-dependent cysteine protease (EC 3.4.22.17; Clan CA, family C02). Recent expansion of sequence data across the species definitively shows that calpain has been present throughout evolution; calpains are found in almost all eukaryotes and some bacteria, but not in archaebacteria.

2024年10月1日 · Emerging studies indicate that Calpain, a crucial protease responsible for intracellular protein degradation, contributes significantly to the pathophysiology of cardiovascular and cerebrovascular diseases. Calpain normally operates under tight regulatory control to maintain cellular balance [8].

2020年8月31日 · Calpain是一类在多种生物体内广泛表达的钙依赖的蛋白酶，且与多种生理功能和病理过程如局部脑缺血和神经退行性疾病等相关。 在正常生理状态下，细胞内钙浓度平均水平只有100纳摩尔，远低于体外激活Calpain所需的微摩尔和毫摩尔钙浓度。