Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. This class of enzymes is divided up into a number of subcategories, including CYP1, CYP2, and CYP3, which as a group are largely responsible for the breakdown ...

Besides the detoxifying role of CYP2E1 for compounds such as electrophilic agents, reactive oxygen species, free radical products, and the bioactivation of xenobiotics, CYP2E1 is also related in several diseases and pathophysiological conditions.

CYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions. This chapter focuses on the discussion of CYP2E1 in ethanol metabolism in the CNS, covering topics including how it is regulated, where it is expressed and how it influences sensitivity to ethanol in the brain. 8.1 Introduction

Mar 30, 2025 · CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Alcoholic Liver Cirrhosis and Alcohol Use Disorder . Among its related pathways are Sevoflurane Pathway, Pharmacokinetics and Oxidation by cytochrome P450 .

CYP2E1 has the highest catalytic activity among the members of cytochrome P450 enzymes in metabolizing alcohol (ethanol). The role of CYP2E1 becomes particularly important when CYP2E1 is upregulated following chronic and acute alcohol exposure in hepatocytes and in wild-type (WT) animals [1, 44, 48].

Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity and cancers (e.g. lung and bladder cancer), since it is responsible for metabolizing a number of medications and environmental toxins to reactive intermediate metabolites.

CYP2E1 is located within the placental trophoblast, and has been detected in this tissue during all three trimesters (Hakkola et al. 1996). CYP2E1 is most notably involved in the bioactivation of procarcinogens and metabolism of low-molecular-weight compounds.

This review describes some of the biochemical and toxicological properties of CYP2E1, especially as it relates to alcohol metabolism and toxicity and the establishment of human hepatoma HepG2 cell lines that overexpress human CYP2E1.

Dec 25, 2001 · Hepatic CYP2E1 content significantly correlated with the maximal 6-hydroxychlorzoxazone concentration (r=0·76, P < 0·001) and other pharmacokinetic parameters (chlorzoxazone clearance and 6-hydroxychlorzoxazone AUC). CONCLUSIONS. This review mainly deals with the role of human CYP2E1 in the clinical and toxicological effects of drugs.

Human microsomal cytochrome P-450 2E1 (CYP2E1) monooxygenates >70 low molecular weight xenobiotic compounds, as well as much larger endogenous fatty acid signaling molecules such as arachidonic acid.