Genes encoding P450 enzymes, and the enzymes themselves, are designated with the root symbol CYP for the superfamily, followed by a number indicating the gene family, a capital letter indicating the subfamily, and another numeral for the individual gene.

细胞色素P450（cytochromeP450或CYP450,简称CYP450）代表着一个很大的可自身氧化的亚铁血红素蛋白家族，属于单氧酶的一类，因其在450纳米有特异吸收峰而得名。 它参与内源性物质和包括药物、环境化合物在内的外源性物质的代谢。 根据氨基酸序列的同源程度，其成员又依次分为家族、亚家族和酶个体三级。 细胞色素P450酶系统可缩写为CYP，其中家族以阿拉伯数字表示，亚家族以大写英文字母表示，酶个体以阿拉伯数字表示，如CYP2D6、CYP2C19、CYP3A4 …

Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall ...

By checking your DNA for certain gene variations, CYP450 tests that include CYP2D6 tests and CYP2C19 tests can offer clues about how your body may respond to a specific antidepressant. Genotyping tests, such as cytochrome P450 tests, may speed up the time it takes to find medicines that the body can process better.

Understanding the CYP system is essential for advanced practitioners (APs), as the consequences of drug-drug interactions can be profound. In this article, we will describe the CYP system, its potential for drug interactions, and the genetic polymorphisms that can exist in hematology/oncology patients.

2022年9月6日 · Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple CYP variants constitute clinically relevant biomarkers for the guidance of drug...

There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 families; these three families are also the ones that are dramatically larger in rodent genomes.

2025年3月30日 · CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP1B1 include Glaucoma 3, Primary Congenital, A and Anterior Segment Dysgenesis 6. Among its related pathways are Fatty acid metabolism and Metapathway biotransformation Phase I and II.

2000年1月6日 · Cytochrome P450 proteins, named for the absorption band at 450 nm of their carbon-monoxide-bound form, are one of the largest superfamilies of enzyme proteins. The P450 genes (also called CYP) are found in the genomes of virtually all organisms, but their number has exploded in plants.

2018年1月22日 · Cytochromes P450 in humans (and most vertebrates) are divided into 18 CYP gene families – based on amino acid sequence similarity. CYP gene polymorphisms can alter a person's ability to metabolise drugs (poor, intermediate, efficient or ultrarapid metabolisers).