《自然·免疫学》：肿瘤“流放”T细胞！科学家首次揭示肿瘤通过淋巴管外排T …
2023年3月2日 · Lund团队的研究结果表明，肿瘤相关淋巴管内皮细胞会产生趋化因子CXCL12，CXCL12与T细胞表面的受体CXCR4结合后，会促进T细胞顺着淋巴管离开肿瘤，被 …
CXCR4 - Wikipedia
CXCR-4 is an alpha- chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 is …
Expression of CXCR4 on T-cell subsets and Plasma IL-17 ... - Nature
2017年8月22日 · Acquired aplastic anaemia (AA) is caused by T-cells migrating to and attacking bone marrow (BM) in response to chemokines (e.g., CXCR4). We investigated CXCR4 …
CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T ...
2024年9月23日 · CXCR4 is highly expressed in CD8 + PD-1high exhausted T cells within tumors. Blocking CXCR4 enhances immunotherapy by reducing exhausted CD8 + T cell phenotype. …
CXCR4 Physically Associates with the T Cell Receptor to Signal in T …
2006年8月1日 · SDF-1α (CXCL12) signaling via its receptor, CXCR4, stimulates T cell chemotaxis and gene expression. The ZAP-70 tyrosine kinase critically mediates SDF-1α-dependent …
《普创新》趋化因子受体CXCR4及其配体 - 知乎 - 知乎专栏
CXCR4的基础表达主要受 核呼吸因子1 (Nuclear Respiratory Factor 1 ,NRF-1)和 核转录因子Yin-Yang 1 (YY1)的调节，前者促进受体转录，而后者负调节 [9,10]。 CXCR4响应不同的信号分子 …
CXCR4-enriched T regulatory cells preferentially home to bone …
2024年9月20日 · CXCR4 cell surface expression is critical for the homing of T regulatory (Treg) cells to the bone marrow (BM). We hypothesize that CXCR4 enrichment on Tregs cell surface …
CXCR4 Is Required for Leukemia-Initiating Cell Activity in T Cell …
2015年6月8日 · Passaro et al. show that CXCR4 is important for T cell acute lymphoblastic leukemia (T-ALL) propagation in vivo and that calcineurin regulates cortactin-dependent …
CXCR4 to improve both T cell homing and function
2023年5月25日 · In this issue of Blood, Biondi et al 1 show that enforcing CXCR4 expression on CD33-targeting chimeric antigen receptor (CAR) cytokine-induced killer (CIK) cells enhances …
CXCR4 expression on pathogenic T cells facilitates their bone …
In this study, we show that CXCR4 is highly expressed on BM-infiltrating CD4 + and CD8 + T cells in a mouse model of AA. Inhibiting CXCR4 in AA mice, using CXCR4 −/− splenocytes or …