CXCR4 is one of several chemokine co-receptors that HIV can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these …

Among chemokine receptors, CXCR4 is the most widely expressed, and is involved in numerous physiological and pathological conditions. CXCR4 is expressed by most cells, including …

The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors (GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They play a key role …

6 天之前 · CXCR4 (C-X-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CXCR4 include Whim Syndrome 1 and Macroglobulinemia, Waldenstrom 1. …

2024年9月23日 · We show that CXCR4 adopts distinct subunit conformations in trimeric and tetrameric assemblies, highlighting how oligomerization could allosterically regulate chemokine …

2020年8月27日 · The CXCR4 receptor upon binding its ligands triggers multiple signaling pathways that orchestrate cell migration, hematopoiesis and cell homing, and retention in the …

This review provides an overview of the role of the C-X-C chemokine receptor type 4 (CXCR4) in B-cell development and in B cell–mediated disorders.

2015年1月22日 · CXCR4 is a rare CXC receptor that possesses a sulfotyrosine in the proximal N terminus (position C-7) (fig. S4C), which may explain its ability to engage a CC chemokine …

CXCR4 promotes migration, invasion, and epithelial-mesenchymal transition of papillary thyroid carcinoma by activating STAT3 signaling pathway. Comprehensive Analysis of CXCR4, JUNB, …

2018年5月7日 · CXCR4 has been shown to be a master regulator of neutrophil retention in the bone marrow and mobilisation during inflammatory responses in mouse at least and …