Jun 11, 2020 · C-X-C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10 kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell …

In this review, we focus on current research elucidating the emerging role of CXCL10 in the pathogenesis of cancer. Understanding the role of CXCL10 in disease initiation and progression may provide the basis for developing CXCL10 as a potential biomarker and therapeutic target for related human malignancies. Keywords: chemokine, CXCL10, cancer. 1.

Mar 30, 2025 · CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Spotted Fever and Cryptosporidiosis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and GPCR downstream signalling.

CXCL10, known as interferon γ-induced protein 10 (IP-10), is strongly induced by IFN-γ as well as by IFN-α/β and weakly by TNFα.

Jul 1, 2023 · CXCL10 was also proved to regulate tumor immune microenvironment of ovarian cancer, leading to strong immune cell infiltration. It can activate immune killing response and suppress angiogenesis...

CXCL10, also known as interferon (IFN) γ-inducible protein (IP)−10, is a 8.7 kDa chemokine that has both pro-inflammatory properties and protective physiological functions, including facilitation of angiogenesis and cell-to-cell communication between glia and neurons (Gotsch et al., 2007; Michlmayr and Mckimmie, 2014; Xia et al., 2000).

The current review focuses on a key chemokine named CXCL10 and its role in directing the migratory propertied and biological function of CD4+ and CD8+ T cells in the context of cancer and inflammatory autoimmunity.

Jun 4, 2015 · Interferon- γ -inducible protein CXCL10 (IP-10) is a small (10 kDa) secretable protein in the CXC subfamily of cytokines. Consistent with known functions of CXC cytokines, CXCL10 mediates...

3 days ago · The study identified two new immunomarker ratios - IL- 1β/IL- 1RA and CXCL8/CXCL10 - as potential predictors of wound healing status. The IL- 1β/IL- 1RA ratio showed the highest accuracy for distinguishing healing from non-healing wounds (AUC = 0.6837), while the CXCL8/CXCL10 ratio was most effective in identifying infection (AUC = 0.7669).

Mar 26, 2025 · HIV-1 and the viral protein Tat modulate the expression of chemokine (C-X-C motif) ligand 10 (CXCL10; IP-10) in immature dendritic cells and monocyte-derived macrophages: PubMed: tat: The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human ...