免疫细胞表面的TLR9及其免疫调节作用 - 知乎 - 知乎专栏
Toll样受体9 （TLR9）是Toll样受体家族的成员之一，其可被病原体来源的非甲基化磷酸胞苷鸟苷DNA（ CpG DNA ）或人工合成的含非甲基化CpG的 寡核苷酸 （CpG ODN）激活，并通过其 …
High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9 ...
2013年5月14日 · Unveiling a previously undescribed role for TRIF and TRAF6 proteins in Toll-like receptor 9 (TLR9) signalling, we demonstrate that physical association of TLR9, TRIF and …
Toll-like receptor 9 agonists and combination therapies ... - Nature
2022年7月28日 · In this review article, we describe the TLR9 signaling, the application of TLR9 agonists CpG-ODN in tumour biology, the delivery methods and focus on the combination …
TLR9激动剂-CpG ODNs - 知乎 - 知乎专栏
CpG-A ODNs刺激类浆树突细胞（pDC）可以较强的产生 IFN-a，但是会较弱的激活TLR9依赖的 NF-kB 信号通路，产生较少的促炎性细胞因子（如白细胞介素6）。 - CpG-B ODNs 是包含一 …
TLR9 signals after translocating from the ER to CpG DNA in the …
2004年1月11日 · We show that CpG DNA binds directly to TLR9 in ligand-binding studies. CpG DNA moves into early endosomes and is subsequently transported to a tubular lysosomal …
Spatially Controlled Activation of Toll-like Receptor 9 with DNA …
2022年3月10日 · We exploit the recent characterization of the CpG-TLR9 interaction in published crystallography studies (17−19) combined with the unique spatial control of ligands on DNA …
Development of CpG oligodeoxynucleotide TLR9 agonists in anti …
2021年4月15日 · Introduction: Toll-like receptor-9(TLR9) can recognize the foreign unmethylated CpG DNA, and thus intrigue a strong Th1 response which plays a crucial role in the innate and …
Toll-like Receptor 9 Contains Two DNA Binding Sites that …
TLR9 recognizes DNAs with unmethylated CpG motifs and activates innate immune responses. Ohto et al. identify another TLR9 binding motif, the 5′-xCx DNA motif, and determine the …
CpG oligodeoxynucleotides as TLR9 agonists: therapeutic
TLR9, which recognizes unmethylated CpG (cytosine guanosine dinucleotide), is a very promising target for therapeutic activation. Stimulation of TLR9 activates human plasmacytoid dendritic …
Toll-like receptor 9, CpG DNA and innate immunity - PubMed
Recent studies indicate that mucosal or systemic delivery of CpG DNA can act as a potent adjuvant in a vaccine combination or act alone as an anti-microbial agent. Recently, it was …
- 某些结果已被删除