Neuronal acetylcholine receptor subunit alpha-4, also known as nAChRα4, is a protein that in humans is encoded by the CHRNA4 gene. [5] [6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAChR). Alpha4-containing nAChRs (specifically the alpha4beta2 subtype) appear to play a crucial role in the ...

2025年3月30日 · CHRNA4 (Cholinergic Receptor Nicotinic Alpha 4 Subunit) is a Protein Coding gene. Diseases associated with CHRNA4 include Epilepsy, Nocturnal Frontal Lobe, 1 and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy. Among its related pathways are Postsynaptic nicotinic acetylcholine receptors and Transmission across Chemical Synapses.

2023年12月7日 · 王丽蕊团队发现CHRNA4能够特异性表达在肝实质细胞中，并且在MASH小鼠和患者的肝脏中显著上升，与MASH严重程度正相关。 此外，研究人员发现CHRNA4内源性配体乙酰胆碱的来源是肝脏中的免疫细胞，这些细胞在MASH发展过程中数量增多，产生更多的乙酰胆碱以激活并上调肝实质细胞中的CHRNA4。 另一方面，尼古丁是CHRNA4的外源性配体，也能够激活并上调CHRNA4的表达。...

该基因编码烟碱型乙酰胆碱受体，属于配体门控离子通道超家族，在突触的快速信号传输中发挥作用。 这些五聚体受体可以结合乙酰胆碱，从而引起构象的广泛变化，从而导致跨质膜的离子传导通道打开。 这种蛋白质是一种完整的膜受体亚基，可以与 nAChR beta-2 或 nAChR beta-4 相互作用形成功能性受体。 该基因的突变会导致 1 型夜间额叶癫痫。 该基因的多态性可防止尼古丁成瘾，已有报道。 可变剪接导致多个转录本变体。 [RefSeq 提供，2012 年 2 月]

2025年3月26日 · Title: Autosomal dominant sleep-related hypermotor epilepsy caused by a previously unreported CHRNA4 variant. Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of alpha4beta2- nicotinic …

The CHRNA4 gene provides instructions for making one part (subunit) of a larger protein called a neuronal nicotinic acetylcholine receptor (nAChR). Learn about this gene and related health conditions.

The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha-4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2.

2024年12月10日 · These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.

2024年8月28日 · The α4β2 nAChRs are crucial ion channels that control neurotransmitter release and play a role in various physiologic and pathologic processes. CHRNA4 encodes the α4-nAChRs, while CHRNB2 encodes the β2-nAChRs. Recent studies have found different variants of α4β2-nAChRs in individuals with conditions …

2025年2月8日 · these results provide evidence for a change in neural impulse activity received by skeletal muscles associated with a knock-in mutation in CHRNA4 expressed in the brain. Alpha4beta2-type nicotinic receptors are critical for acetylcholine-stimulated release of gamma-aminobutyric acid from brain synaptosomes in cortex, hippocampus, striatum, and ...