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Background: Chronic granulomatous disease (CGD) is characterized by recurrent life-threatening bacterial and fungal infections and aberrant inflammation. Mutations in CYBB cause X-linked CGD and account for 65% to 70% of cases in Western countries.

慢性肉芽肿病（chronic granulomatous disease，CGD）是我国原发性免疫缺陷病中常见的类型之一，是由烟酰胺腺嘌呤二核苷酸磷酸（nicotinamide-adenine dinucleotide phosphate，NADPH）氧化酶复合物缺陷导致超氧化物的合成下降，从而引起以NADPH酶阳性菌感染及肉芽肿性炎症为主要 ...

Aug 9, 2012 · Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder of phagocytes (neutrophils, monocytes, macrophages, and eosinophils) resulting from impaired killing of bacteria and fungi.

Jan 1, 2018 · Chronic granulomatous disease (CGD) is characterized by recurrent life-threatening bacterial and fungal infections and aberrant inflammation. Mutations in CYBB cause X-linked CGD and account for 65% to 70% of cases in Western countries. We sought to understand the clinical manifestations associated with the X-linked CGD carrier state.

Oct 4, 2016 · Chronic granulomatous disease (CGD) is an innate immunodeficiency with a genetic defect of the nicotinamide adenosine dinucleotide phosphate, reduced, oxidase components. This leads to decreased reactive oxygen species (ROS) production, which renders patients susceptible to life‐threatening infections.

Mar 1, 2020 · Chronic granulomatous disease (CGD) is an inherited defect of phagocyte function due to defective NADPH oxidase. Patients with CGD are not able to effectively clear the infections because of the defect in the phagocyte production of oxygen free radicals and are prone to recurrent bacterial and fungal infections.

Nov 26, 2012 · Chronic granulomatous disease (CGD) is a single gene defect that can be reconstituted in vitro and does not require complete correction to be effective, as proven by the normal lives of many X-linked carriers, and by the stable chimeras generated in …

Apr 21, 2022 · CGD is characterized by severe recurrent bacterial and fungal infections and dysregulated inflammatory responses resulting in granuloma formation and other inflammatory disorders such as colitis. Infections typically involve the lung (pneumonia), lymph nodes (lymphadenitis), liver (abscess), bone (osteomyelitis), and skin (abscesses or cellulitis).