2025年3月28日 · CD83 (CD83 Molecule) is a Protein Coding gene. Diseases associated with CD83 include Neonatal Infective Mastitis and Plague. Among its related pathways are Macrophage markers and NF-kappaB Signaling. May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. ( …

Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). mCD83 regulates maturation, activation and homeostasis.

Several studies revealed that CD83 is not a typical co-stimulatory molecule, but rather plays a critical role in controlling and resolving immune responses. Moreover, CD83 is an essential factor during the differentiation of T and B lymphocytes, and the …

2019年6月7日 · Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). mCD83 regulates maturation, activation and homeostasis.

2020年4月17日 · The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form are topic of intensive research investigations.

The activation of dendritic cells (DCs) can influence immunological responses by promoting the differentiation of T cells into various functional subtypes crucial for the eradication of pathogens. CD83 is a molecule known to be expressed on mature DCs, activated B cells, and T cells.

CD83 is preformed inside imDCs and rapidly induced on the cell surface upon DC activation. Upon activation, DCs increase surface expression of MHC and other molecules involved in antigen presentation, e.g. CD40, CD54, CD80 and CD86 [7,8]. CD83 is expressed on activated human DCs as a specific maturation marker.

2023年8月1日 · Here, we describe a thorough assessment of CD83 regulation in microglia and show that CD83 expression in murine microglia is not only associated with cellular activation but also with...

2023年3月11日 · CD83, a member of the immunoglobulin superfamily, is a novel marker to discriminate precursor exhausted T cells from terminally exhausted and bystander tumor-infiltrating T-lymphocytes.

The transmembrane CD83 molecule, a conserved member of the immunoglobulin superfamily, is known as one of the most characteristic cell surface markers for fully matured dendritic cells (DCs) in the peripheral circulation.