CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene. [5] [6] It is also known as 26 kDa cell surface protein, TAPA-1 (Target of the Antiproliferative Antibody 1), and Tetraspanin-28 (Tspan-28).

cd81是四跨膜蛋白超家族（tm4sf）成员之一，可以与其他四跨膜蛋白、整合素、辅助受体、mhc i类或ii类分子形成复合物，影响b、t细胞的粘附、形态、激活、增殖和分化。

2025年3月28日 · CD81 (CD81 Molecule) is a Protein Coding gene. Diseases associated with CD81 include Immunodeficiency, Common Variable, 6 and Common Variable Immunodeficiency. Among its related pathways are Complement cascade and Innate Immune System. Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding.

CD81是TM4SF成员,为分子量为25kD的跨膜四分子蛋白,它表达广泛,在90%Burkitt淋巴瘤细胞株细胞表现有表达。 它四次跨越细胞膜，在细胞外形成大小两个环状结构。

2023年12月22日 · CD81（又名Tetraspanin-Associated Protein 1，TAPA-1）是首个被认定的HCV感染靶细胞的受体分子，最初是在筛选能抑制B淋巴细胞瘤增殖的单克隆抗体的过程中被发现的，属于四次跨膜蛋白超家族（Tetraspanins/TM4SF）（点击了解“什么是TM4SF家族”）。CD81由四个跨膜区、两个胞 ...

cd81是一种具有多种生物学活性的四次跨膜蛋白，几乎广泛表达于人体的所有组织。 CD81参与蛋白合成转运及激活、微绒毛的形成与延伸、淋巴细胞免疫活化等多种生理反应过程，在病原体感染、过敏性皮炎、动脉粥样硬化、脑脊髓炎、肿瘤、先兆子痫、系统性 ...

2021年11月25日 · If CD81 gene expression could be controlled by ON or OFF Pax5-expression, Pax5-mediated CD81 regulation may be useful for the treatment of B cell lymphoma using anti-CD81 antibodies.

Anti-CD81 can activate integrin α4β1(VLA-4) on B cells, facilitating their adhesion to tonsilar interfollicular stroma. Similarly, anti-CD81 can activate αLβ2 (LFA-1) on human thymocytes. CD81 can also affect cognate B-T cell interactions because anti-CD81 increases IL-4 synthesis by T cells responding to antigen presented by B cells but ...

cd81 分子： 由该基因编码的蛋白质是跨膜 4 超家族的成员，也称为四跨膜蛋白家族。 这些成员中的大多数是细胞表面蛋白，其特征在于存在四个疏水结构域。

2024年12月10日 · Overexpression of CD81 and CD9 renders cells less susceptible to HIV-1 gp120/gp41-mediated syncytia formation; antibodies raised against CD9 and CD81 enhance syncytia formation: PubMed: env: CD81 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles: PubMed