cd8+ t细胞是一种效应性t细胞，主要负责清除感染的细胞和肿瘤细胞。 当内源性抗原被细胞自身处理后，会形成MHC-I-抗原复合物，然后与CD8+ T细胞相互作用。

2023年11月28日 · Major histocompatibility complex (MHC) class II-reactive CD8 + T cells are found in humans and animals, but little is known about their identity, development, and function. In this study, we discover a group of CD8 + T cells reactive to both MHC class I and II molecules in MHC class II-deficient mice.

被 cd8+ t细胞 识别 → 启动细胞毒杀伤反应。 mhc-ii：处理外源性抗原（细胞吞噬后处理） 巨噬细胞、dc、b细胞等 apc 摄取外源抗原； 在内体/溶酶体中水解降解成小片段； 与 mhc-ii 分子结合后，迁移至细胞膜；

近日，来自美国华盛顿大学圣路易斯分校的Robert D. Schreiber团队在Nature杂志上在线发表题为MHC-II neoantigens shape tumour immunity and response to immunotherapy的文章，发现有效的抗肿瘤反应，既需要识别肿瘤抗原的 CD8+T细胞 ，同时也需要CD4+T细胞。

Major histocompatibility complex (MHC) class II-reactive CD8+T cells are found in humans and animals, but little is known about their identity, development, and function. In this study, we discover a group of CD8+. T cells reactive to both MHC class I and II molecules in MHC class II …

MHC I and II molecules present protein fragments to CD8+ and CD4+ T cells, respectively. These molecules are essential for cell-mediated immunity and therefore appeared at the inception of the adaptive immune system, some 500 million years ago [1].

2023年1月12日 · Kilian et al. show that in brain tumors, loss of MHC class II drives TOX-mediated CD8+ T cell dysfunction by increased osteopontin expression. This study highlights that MHCII-restricted antigen presentation on brain tumor-associated myeloid cells is a key mechanism to maintain functional cytotoxic T cell states.

In contrast to human CD8 + T cells, murine CD8 + T cells lack the transcription factor CIITA, a master regulator of H2‐Ab (MHC‐II) gene expression. 26 However, MHC‐II is highly expressed on antigen‐presenting cells (APCs) and our results are the first to demonstrate in vivo that CD38 + CD8 + T cells can ‘snatch’ MHC‐II, along with ...

2021年9月8日 · Overall, our study demonstrates that both virus-specific and bystander CD38 + MHC-II + CD8 + T cells are recruited to the site of infection during severe disease, and that MHC-II presence occurs via trogocytosis from antigen-presenting cells. Our findings highlight the i …

2012年7月7日 · Most strikingly, naïve CD8 T cells isolated from H-2M −/− mice exhibited similar hyperproliferation as MHC II −/− CD8 T cells, suggesting that peptides loaded onto MHC II molecules are involved in regulating the CD8 T-cell responses. Taken together, our results suggest that interactions between self-peptide-MHC II complexes and CD8 T ...