2023年5月24日 · 研究发现， CD69 在维持Treg免疫抑制功能中起重要作用，Treg中敲低CD69容易诱发炎症性肠病等自身免疫性疾病。 此外， HSF1 通过激活CD69转录促进CD69+Tregs分化，这对Tregs的免疫抑制功能至关重要。 尤其是对于治疗自身免疫性疾病的患者来说，通过增加CD69+Treg的数量将有望缓解疾病症状，改善病情进展。 CD69作为淋巴细胞活化最早表达的分子，也就是当免疫系统激活时，CD69成为最早的信号，调节T细胞、B细胞、自然杀伤细胞等多 …

2021年4月7日 · 这些研究表明，CD69是T细胞活化后上调的 最早标志物之一，CD69表达的早期动力学和广泛分布使其成为在体外刺激试验中鉴定抗原反应性T细胞并有效纯化这些细胞的理想方法。 但是，由于它会随细胞增殖而稀释，因此不能用于长期刺激试验。 此外，当直接进行体外研究而不进行体外再刺激时，用CD69评估T细胞活化可能严重低估了体内活化T细胞的比例。 最后，细胞增殖的标志物可以用作T细胞活化的替代标记（因为增殖需要活化）。 实际上，Ki-67的检 …

CD69-deficient CD4 + T cells were found to express lower levels of CD154 than wild-type controls, suggesting this deficiency may contribute to their defective helper function. A range of other functionally relevant parameters are found to be normal in CD69 −/− CD4 + T cells, however, including the ability to generate phenotypically normal T ...

2009年1月1日 · In this study, we have identified tumor-induced CD69 + CD4 + CD25 − T cells as a new subset of CD4 + Treg cells. CD69 + CD4 + CD25 − T cells increase dramatically along tumor progression, with up to 40% of CD4 + T cells in the advanced tumor-bearing mice.

CD69 is a membrane-bound, type II C-lectin receptor. It is a classical early marker of lymphocyte activation due to its rapid appearance on the surface of the plasma membrane after stimulation. CD69 is expressed by several subsets of tissue resident ...

2019年7月24日 · Adaptive immune cells, including CD4+CD69+ and CD4+CD25+FoxP3+ regulatory T (Treg) cells, are important for maintaining immunological tolerance. In human systemic lupus erythematosus (SLE), CD4+CD25+FoxP3+ Treg cells are reduced, whereas CD69 expression is increased, resulting in a homeostatic immune imbalance that may intensify autoreactive T ...

2012年5月21日 · This finding suggests that CD69 expression directs the memory CD4 + T cells to specialized niches where they might receive the necessary cytokine and survival signals involved in their transition to the resting yet reactive state that is observed in the study by Shinoda et al.

Recently, the engagement of CD69 by its ligand oxLDL has been shown to induce the expression of the immunoregulatory molecule PD-1 on human CD4 + T cells (Jiménez-Fernández et al., 2022). Cd69 deficient mice showed enhanced T cells and NK-mediated anti-tumor responses due to increased IFNγ secretion and cytolytic activity, respectively ...

2009年1月1日 · CD69(+)CD4(+)CD25(-) T cells increase dramatically along tumor progression, with up to 40% of CD4(+) T cells in the advanced tumor-bearing mice. Distinct from the previously described CD4(+) Treg cell subsets, CD69(+)CD4(+)CD25(-) T cells express high CD122, but they do not express Foxp3 and secrete IL-10, TGF-beta1, IL-2, and IFN-gamma.

2025年3月17日 · CD69 is one of the earliest surface markers to appear on T cells following activation, with its expression detectable within hours of antigenic stimulation. This rapid upregulation occurs across both CD4⁺ and CD8⁺ T cell subsets.