Osteopontin and iCD8α Cells Promote Intestinal Intraepithelial ...
2020年4月1日 · Moreover, we show in vitro that exogenous osteopontin stimulates the survival of murine IEL subpopulations and unfractionated IEL derived from human intestines, an effect …
Differences in CD44 Surface Expression Levels and Function ...
CD44 is a prominent activation marker which distinguishes memory and effector T cells from their naïve counterparts. It also plays a role in early T cell signaling events as it is bound to the …
CD44与CD62L对肿瘤细胞和T细胞的标记意义 - 知乎
CD44主要参与细胞黏附、迁移和肿瘤生物学，是肿瘤干细胞的标志物，具有重要的临床应用价值。 由于其在肿瘤干细胞中的高表达，CD44已成为肿瘤治疗的潜在靶点。
TGF-β controls development of TCRγδ - Nature
2023年5月30日 · Mechanistically, TGF-β is required for the development of TCRγδ + CD8αα + IELs thymic precursors (CD44 – CD25 – γδ thymocytes). In addition, TGF-β signaling induced …
CD44 Intracellular Domain: A Long Tale of a Short Tail - MDPI
2023年10月18日 · Currently, CD44 is an established cancer stem cell marker in several tumors, implying a central functional role in tumor biology. The present review aims to highlight the …
An SSTR2–somatostatin chemotactic axis drives T cell ... - Nature
2025年3月26日 · Progenitors of intraepithelial T cells (IELps) migrate from the thymus to the intestines after birth where they can develop into unconventional intraepithelial lymphocytes. …
Interleukin-7 administration alters intestinal intraepithelial ...
2005年9月21日 · IL-7 administration significantly increased IEL numbers. CD8αβ+ IEL increased 3.2-fold, CD8+CD44+ IEL increased 1.3-fold, and αβ-T-cell receptor (TCR)+ IEL increased 1.3 …
Myeloid cells direct recruitment of colon intraepithelial …
2021年5月1日 · To understand how the IEL-IEC synapse affects IEL function, we utilized Villin-Cre + MHCII fl/fl mice. We observed altered maturation in both CD4+ and CD4− CD8− IEL …
靶向肿瘤干细胞的药物开发靶点：CD44 - 知乎
CD44以HA依赖性或HA非依赖性参与调节 MMPs 表达，特别是MMP2和MMP9，降解细胞外基质（ECM），促进肿瘤的侵袭和转移。 CD44调节细胞周期相关蛋白的水平，包括细胞周期蛋 …
Alteration of the Intestinal Intraepithelial Lymphocytes during …
1998年10月1日 · Isolated IEL were stained for CD4, CD8, and CD44 (as a marker for memory T-cells) and flow cytometry was performed. mRNA was extracted from remaining IEL for …