2012年1月1日 · Aggressively growing cell lines displayed ERK1/2 activation, which stimulated expression of CD44, a marker associated with epithelial to mesenchymal transition and putative cancer stem cells. MEK (MAP/ERK kinase) inhibition upstream of ERK1/2 decreased CD44 expression and promoter activity and reduced cell migration and invasion.

2021年8月12日 · CD44 overexpression significantly increased migration and invasion abilities of lung cancer cells through CD44-induced ERK phosphorylation, ZEB1 upregulation, and Claudin-1 downregulation. Furthermore, ERK inhibition suppressed the migration and invasion abilities of CD44-overexpressing lung cancer cells.

We show that CD44 engagement protects CLL cells from spontaneous and fludarabine-induced apoptosis through activation of the PI3K/AKT and MAPK/ERK pathways resulting in increased levels of MCL-1. We find higher CD44 expression and a stronger anti-apoptotic effect of CD44 activation in UCLL cells.

Our in-vitro and in-vivo experiments showed that CD44 downregulation reduced HCC cell colony formation, migration, and invasion, and HCC tumor growth and metastasis, and that the pro-metastasis effect of CD44 was mediated by the protein kinase B (AKT)/extracellular signal-regulated kinase (ERK) signaling-chemokine receptor C-X-C chemokine ...

In this study, we describe a novel crosstalk among ERK, AKT and Hippo-YAP pathways, with CD44 as an upstream regulator. High cell density leads to activation of ERK and AKT but inactivation of YAP in cancer cells. CD44 modulates cell …

2018年5月10日 · CD44 knock-down inhibited ERK 1/2 activation . These findings suggest that ERK might be a CD44 downstream target. Transient knock-down of CD44 in human colon cancer cells resulted in upregulation of AKT, whereas overexpression of variant isoforms of CD44 such as v3-10 or v8-10 caused deactivation of AKT.

2003年1月1日 · First, CD44 can undergo passive or regulated ligand binding. This includes adhesion to hyaluronan and other components of the extracellular matrix, as well as axon deterrence and action as a...

CD44 的二聚化激活了 PI3K/AKT 和 MAPK/ERK 通路并导致 MCL-1 水平增加。 CD44 刺激的细胞中 MCL mRNA 没有增加，与对蛋白质稳定性的影响一致。 与这些抗凋亡机制的诱导一致，CD44 保护 CLL 细胞免于自发性凋亡：CD44 刺激的 CLL 细胞的活力比相应的未刺激对照细胞（n = 20，p）增加了 46%（范围 7% – 181%） 慢性淋巴细胞白血病 (CLL) 是成熟 B 细胞的一种无法治愈的恶性肿瘤。 CLL 细胞增殖和存活取决于组织微环境中存在的宿主因素。 在体外，这些细 …

2008年11月16日 · To explore a possible role of this adhesion receptor in CLL, we evaluated the effect of CD44 engagement on the survival of CLL cells and the induction of drug resistance. Dimerization of CD44 activated the PI3K/AKT and MAPK/ERK pathways and resulted in increased levels of MCL-1.

2018年1月11日 · Members of the CD44 family of transmembrane glycoproteins control cell signaling pathways from numerous cell surface receptors, including receptor tyrosine kinases (RTKs). The decisive factor...