Here, we review current data on the structural and functional properties of CD44, the known roles for CD44 in tumorigencity, the regulation of CD44 expression, and the potential for targeting CD44 for cancer therapy.

2025年3月28日 · CD44 (CD44 Molecule (IN Blood Group)) is a Protein Coding gene. Diseases associated with CD44 include Hematologic Cancer and Congenital Dyserythropoietic Anemia. Among its related pathways are Glycosaminoglycan metabolism and Innate Immune System.

2003年1月1日 · CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation.

CD44 is a prominent activation marker which distinguishes memory and effector T cells from their naïve counterparts. It also plays a role in early T cell signaling events as it is bound to the lymphocyte-specific protein kinase and thereby enhances ...

CD44 is a widely distributed transmembrane cell adhesion molecule that is probably the most well-characterized receptor for HA (Aruffo et al., 1990). CD44–HA interaction is involved in various biological events, such as lymphocyte rolling, tumor cell migration, and invasion (Toole, 2004).

CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess several CSC traits, such as self-renewal and epithelial-mesenchymal ...

2017年3月6日 · CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and …

2020年8月3日 · CD44 is a cell-surface adhesion receptor associated with many biological processes that rely on cellular plasticity. Now, CD44 has been shown to mediate endocytosis of iron-bound...

2020年12月10日 · In this review, we focus on current data relevant to CD44, and outline CD44 structure, the regulation of CD44, functional properties of CD44 in carcinogenesis and cancer progression as well as the potential CD44-targeting therapy for cancer management.

1 天前 · CD44, a widely recognized cancer stem cell marker, displayed a vital participation in the cancer immune invasion and may related with the response to the immunotherapy. However, the role of CD44 in cancer immunology is not well defined. Therefore, we intended to explore its prognostic value and potential immunological functions across 33 human cancer types.