Both CD3- and CD3+ CD56+ effector cells can mediate non-MHC-restricted lysis in the absence of activation. Previous studies have shown that both of these subsets can be augmented with IL-2. In the present study, we have examined further the phenotypic markers expressed on these cells as well as the …

CD3 + CD56 + NKT-like cells are a rare population of lymphocytes that serve important roles in various types of immune-related diseases, and particularly in cancer. The complement system regulates inflammatory and immune responses by interacting with complement receptors expressed on a range of immune cells.

2022年4月11日 · CD3 + CD56+ cells exhibited higher expression of cellular protective proteins than CD3+ cells in both stimulated and control, nonstimulated cells. NKT-like and T cells showed a distinct sensitivity to the applied stimulatory factors in the respective age groups.

CD56 is the archetypal phenotypic marker of natural killer cells but can actually be expressed by many more immune cells, including alpha beta T cells, gamma delta T cells, dendritic cells, and monocytes.

2021年4月12日 · CD3- (CD56 or 16)+ NK cell counts and percentages in healthy adults were highly variable, not Gaussian distributed and independent of age and sex. NK cell percentages ranged from 1.9 to 37.9% of lymphocytes, and were significantly more dispersed in AAV (0.3 to 57.6%), while the median percentage was not different between AAV and healthy donors.

CD56 + T cells are a group of pro-inflammatory CD3 + lymphocytes with characteristics of natural killer cells, being involved in antimicrobial immune defense. Here, we performed deep phenotypic profiling of CD3 + CD56 + cells in peripheral blood of normal human donors and individuals sensitized to birch-pollen or/and house dust mite by high ...

Our results show that CD3 + CD56 + NK T cells are significantly decreased in the peripheral blood of patients with psoriasis relative to the healthy controls. This finding is discussed in relation with the development of a type 1 immune response in psoriasis.

2011年9月22日 · CD3 + CD56 + cytokine-induced killer (CIK) cells display a potent cytolytic activity. The adhesion molecule lymphocyte function-associated antigen-1 plays a crucial role in binding as well as in cytolytic activity of CIK cells against tumor target cells expressing the corresponding ligands.

2020年11月24日 · Here, we performed deep phenotypic profiling of CD3 + CD56 + cells in peripheral blood of normal human donors and individuals sensitized to birch-pollen or/and house dust mite by high-dimensional mass cytometry combined …

2024年10月1日 · NKT-like cells (CD3 +CD56+) in premalignant lesions and cervical cancer represent a heterogeneous population divided into four unique cellular clusters with different receptor expression. NKT-like cells express NKG2D and DNAM-1 activating immune checkpoints receptors and co-express inhibitory immune checkpoints receptors (PD-1 and TIGIT).