The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and
2023年7月10日 · Using patient-derived co-cultures, humanized mouse models, and single-cell RNA-sequencing of patient melanomas biopsied before and on immune checkpoint blockade, …
The CD58–CD2 axis in cancer immune evasion - Nature
2022年5月19日 · Previous work has found that downregulation of CD58, the co-stimulatory ligand for CD2, is associated with immune evasion in melanoma tumours and that ICB treatment of …
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and …
2023年6月15日 · We show that CD58 is crucial for infiltration of tumors by T cells, likely via its adhesive properties when ligated with CD2, and that increased CD58 co-stimulatory signaling …
CD58 Immunobiology at a Glance - PMC - PubMed Central (PMC)
In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and …
Overcoming the Lack of CD2:CD58 Costimulation in Chimeric …
2024年11月5日 · CD58 loss in cancer cells leads to CAR T cell resistance and CD2-dependent T cell engagement in the tumor microenvironment is essential for sustained cytotoxicity. …
A dynamic CD2-rich compartment at the outer edge of the ... - Nature
2020年9月14日 · CD2–CD58 interactions in the corolla boosted signaling by 77% as compared with central CD2–CD58 interactions. Engaged PD-1 invaded the CD2 corolla and buffered …
PD-L1 and CD58 co-regulated by CMTM6 play yin and yang to
2023年10月9日 · The CD58-CD2 axis regulates T cell-mediated cancer immunity, but little is known about the regulation of CD58. In two recent papers pubished in Cancer Cell, Miao et al. …
The CD2–CD58 axis: A novel marker predicting poor prognosis in …
2023年10月13日 · Our study highlights the CD2–CD58 axis-related immune signature as a valuable prognostic biomarker in LGG patients, with increased CD58 expression potentially …
CD58 Immunobiology at a Glance - PubMed
2021年6月8日 · In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of …
CombiCells allow combinatorial display of cell surface ligands
6 天之前 · We discovered that TCR signalling is enhanced by CD2–CD58 interactions, whereas CAR sensitivity was increased by LFA1–ICAM1 adhesion. ... also showed how signals from …
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