CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, [ 5 ] …

Jun 8, 2020 · CD2 has an important role in the formation and organization of the immunological synapse that is formed between T cells and antigen-presenting cells upon cell-cell conjugation …

Mar 30, 2025 · CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Mastocytosis, Cutaneous and Extracutaneous Mastocytoma. Among its related …

CD2 is a transmembrane molecule belonging to the immunoglobulin supergene family that plays a crucial role in T-cell activation, cytolysis, apoptosis, and cytokine production. It is expressed by …

The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that binds to LFA3, a cell surface protein expressed on e.g., antigen-presenting cells.

Feb 15, 1997 · The CD2 glycoprotein has been implicated in both positive and negative regulation of T-cell mitogenesis. To study the involvement of CD2 in T-lymphocyte development and …

Jun 9, 2020 · Overall, CD2 is an attractive target for monoclonal antibodies intended for treatment of pathologies characterized by undesired T cell activation and offers an avenue to more …

Aug 5, 2022 · CD2 is largely described to promote T cell activation when engaged by its ligands, CD48 in mice and CD58 in humans, that are present on antigen-presenting cells (APCs). …

The CD2 molecule is a 50-55KD transmembrane glycoprotein expressed on the vast majority of thymocytes and virtually all peripheral T lymphocytes. Its functions are two-fold: adhesion and …

CD2 serves as a paradigm for the multitude of adhesion-receptors now being described and characterized. Detailed understanding of each molecule will allow synthesis of an integrated …