CD19 is a 95 kD transmembrane glycoprotein that functions as a co-receptor for the B-cell antigen receptor (BCR) complex on B-lymphocytes. CD19 is expressed throughout B cell development, and it is commonly used as a B cell lineage marker. CD19 plays an important role in B cell activation and humora

Human CD19 (20-291), Fc Tag (CD9-H5259) is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291 (Accession # P15391-1). This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.3 kDa.

CD19 Protein, Human (Biotinylated, Fc) 是重组的 CD19 蛋白，由 HEK293 表达，带有 C-Avi, C-hFc 标签。 CD19 Protein, Human (Biotinylated, Fc) 全长 272 个氨基酸，分子量为 60-90 kDa。 CD19蛋白是B细胞抗原受体辅助受体，可增强下游信号通路，降低激活阈值，帮助B细胞对抗原做出反应。 它激活磷脂酰肌醇 3-激酶并动员细胞内 Ca (2+)。 CD19 Protein, Human (FITC, HEK293, His) 是重组的 CD19 蛋白，由 HEK293 表达，带有 C-His 标签。

B 淋巴细胞抗原 CD19 也称为 CD19（分化簇 19），是一种单通道 I 型膜蛋白，包含两个 Ig 样 C2 型（免疫球蛋白样）结构域。 CD19 在滤泡树突状细胞和 B 细胞上表达。 事实上，从最早可识别的 B 谱系细胞到早期 B 细胞，它存在于 B 细胞上，但在成熟为浆细胞时会丢失。 它主要作为 B 细胞共受体与 CD21 和 CD81 结合。 激活后，CD19 的细胞质尾部被磷酸化，这导致 Src 家族激酶结合并募集 PI-3 激酶。 与T细胞一样，几个表面分子形成抗原受体，并在B淋巴细胞上形成复合 …

Functional Studies - Recombinant human CD19 protein (Fc Chimera Active) (ab167709) ab167709, captured on CM5 chip via Anti-Human lgG Fc antibodies surface, binds FMC63 MAb (mouse lgG2a) with an affinity constant of 3.88 nM, as determined in a SPR assay (Biacore T200) (Routinely tested).

Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also …

CD19 Protein, Human (Biotinylated, Fc) is the recombinant human-derived CD19 protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of CD19 Protein, Human (Biotinylated, Fc) is 272 a.a., with molecular weight of 60-90 kDa.

此外，CD19靶点还被用于开发双特异性抗体（如Blincyto）、抗体药物偶联物（ADC）和Fc工程化抗体等。 CD19靶向疗法在多种血液系统恶性肿瘤的治疗中取得了显著进展。例如，CD19靶向的CAR-T细胞疗法在急性淋巴细胞白血病和B细胞淋巴瘤的治疗中表现出色。

2013年1月29日 · Using the antigen specificity of CAR as the determinant of a more specific reagent for the detection of the CD19-specific CAR, we developed a CD19/Fc molecule that can be labeled for its use primarily as a reagent in flow cytometry studies.