CD147 mediates epidermal malignant transformation through the …
2022年8月13日 · Epidermal CD147-overexpression or knockout (Epi CD147-OE or Epi CD147-KO) transgenic mouse models were generated for in vivo study. RNA-sequencing and q-PCR …
Efficacy of anti-CD147 chimeric antigen receptors targeting ... - Nature
2020年9月23日 · We report that T and NK cells transduced with a CAR that recognizes the surface marker, CD147, also known as Basigin, can effectively kill various malignant HCC cell …
CD147 a direct target of miR-146a supports energy metabolism …
2022年6月8日 · We now confirmed CD147 as miR-146a direct target gene and demonstrate that functional CD147-MCT1 transmembrane complexes are necessary for cellular metabolism …
Engineered CD147-Deficient THP-1 Impairs Monocytic Myeloid
2024年6月16日 · We aimed to engineer CD147 KO THP-1 cells and evaluated their differentiation properties compared to the wild type. A humanized anti-CD147 antibody, HuM6-1B9, was also …
Knockout of CD147 inhibits the proliferation, invasion, and drug ...
2021年6月30日 · To understand whether CD147 can be used as a therapeutic target for oral cancer, CRISPR/Cas9 gene-editing technology was used to knock out the CD147 gene in …
Targeting CD147 for T to NK Lineage Reprogramming and Tumor …
2017年3月28日 · In this study, we analyzed thymocyte development in a mouse strain that carries the conditional CD147 allele and transgenic Cre recombinase under the control of the proximal …
CD147 augmented monocarboxylate transporter-1/4 expression ... - PubMed
Two CD147 knockout (CD147 KO) CCA cell (KKU-213) clones were established using the CRISPR/Cas9 system. Cell migration and invasion were determined using a Boyden chamber …
CD147 对T细胞谱系的维持作用及作为肿瘤免疫治疗靶点的机制研 …
cd147作为一个多功能的跨膜糖蛋白，高表达在多种肿瘤细胞表面，促进肿瘤的侵袭和转移。在肺癌和肝癌治疗中，cd147特异性抗体被证明是有效的治疗手段，并且已经商品化。在免疫系统 …
Knockout of CD147 inhibits the proliferation, invasion, and …
2021年6月30日 · The knockout of CD147 reduced the invasion and expression of MMP2, MMP7, and MMP9 in cal27 cells: (a) The invasiveness of cells was detected by Transwell assay; (b) …
CD147 antibody specifically and effectively inhibits infection …
2021年9月25日 · Here, we identified CD147 as a universal receptor for SARS-CoV-2 and its variants. Meanwhile, Meplazeumab, a humanized anti-CD147 antibody, could block cellular …